April 12, 2010
||Registration (participation fee payment, distribution of
||Opening ceremony with the participation of Prof. Jiří
Drahoš, President of the Academy of Sciences of the Czech Republic
Section 1: Inflammation, cancer and tumor escape
Chairperson: Prof. B. Říhová (Czech Republic)
||Prof. Giorgio Trinchieri, National Cancer Institute,
Frederick, MD, USA:
"Innate resistance, inflammation, and carcinogenesis"
||Prof. Ron N. Apte, Ben Gurion University of the Negev,
Beer-Sheva, Israel: "An interplay between IL-1 and IL-17 in immune/inflammatory
mechanisms in experimental lung metastasis"
||Prof. Angel Porgador, Ben Gurion University of the Negev,
Beer-Sheva, Israel: "Recognition of cancerous state by natural killer cells"
11.25-11.40 Coffee break
Section 2: Immune cells and tumor microenvironment (Part 1)
Chairperson: Prof. R. Apte (Israel)
||Dr. Luca Vannucci, Institute of Microbiology of the ASCR,
v.v.i., Prague, Czech Republic: "Natural killer cells, tumor microenvironment and
influence of immune activation on tumor stroma structures"
||Prof. Jan Bubeník, Institute of Molecular Genetics of the
ASCR, v.v.i., Prague, Czech Republic: "MHC class I downregulation, tumour escape from
immune surveillance and design of therapeutic strategies"
13.00-14.00 Lunch and poster session
(The authors of posters are invited to be present to explain and answer questions)
Section 2: Immune cells and tumor microenvironment (Part 2)
Chairperson: Dr. L. Vannucci (Czech Republic)
||Prof. Viktor Umansky, German Cancer Research
Center, Heidelberg, Germany: "Myeloid-derived suppressor cells in cancer"
||Dr. Licia Rivoltini, National Cancer Institute,
Milan, Italy: "Immunosuppressive mechanisms targeting innate immunity in cancer
15.20-15.30 Coffee break
Section 3: From study toward therapy
Chairperson: Prof. G. Trinchieri (USA)
||Prof. Michael R. Shurin, University of Pittsburgh,
Pittsburgh, PA, USA: "Targeting multiple immune regulators in the tumor
||Prof. Pramod Srivastava, University of Connecticut Health
Center, Farmington, CT, USA: "Heat shock proteins as essential chaperones of
antigenic peptides in direct presentation and cross-priming"
||Assoc. Prof. Radek Špíšek, Charles University, Prague,
Czech Republic: "Exploring dendritic cells for the rational design of prostate cancer
||Prof. Blanka Říhová, Institute of Microbiology of the
ASCR, v.v.i., Prague, Czech Republic: "Cytotoxicity and immunomodulation by
18.20 Prof. Blanka Říhová - Conclusion of the tutorial
part of the workshop
April 13, 2010
Selected abstracts (10 min presentation, 5 min discussion)
Chairpersons: Prof. M. R. Shurin (USA), Prof. P. Srivastava (USA), Prof. V.
||L. Sedláčková, R. Volchenkov, M. Špaček , T. Kozák, I.
Hromadníková: Expression of heat shock protein 70 and NKG2D ligands in human leukemia
cell lines. Third Faculty of Medicine, Charles University in Prague, and University
Hospital Královské Vinohrady, Prague (CZ)
||K. Klimešová, M. Kverka, Z. Zákostelská , P. Rossmann, T.
Hudcovic, O. Kofroňová, O. Benada, J. Mrázek, J. Kopečný, H. Tlaskalová–Hogenová:
Tumor development in mouse model of colitis-associated carcinoma under different microbial
conditions. Institute of Microbiology of the ASCR, v.v.i., Prague, and Institute of Animal
Physiology and Genetics of the ASCR, v.v.i., Prague (CZ)
||L. Kovář, T. Etrych, M. Kabešová, J. Strohalm, O.
Hovorka, K. Ulbrich, B. Říhová: Cancer cells exposed to HPMA conjugates are
preferentially phagocyted by dendritic cells. Institute of Microbiology of the ASCR,
v.v.i., and Institute of Macromolecular Chemistry of the ASCR, v.v.i., Prague (CZ)
||V. Grobárová, V. Benson, R. Křivohlavá, L. Vannucci, A.
Fišerová: Nkrp1c gene divergence influences saccharide-mediated activation of natural
killer cells. Institute of Microbiology of the ASCR, v.v.i., Prague (CZ)
||J. Richter, V. Benson, V. Grobárová, J. Svoboda, J.
Vencovský, R. Svobodová and A. Fišerová: CD161 is responsible for impaired NK cell
cytotoxicity and response to glycans and vimentin in patients with rheumatic diseases.
Institute of Microbiology of the ASCR, v.v.i., Prague, and First Faculty of Medicine,
Charles University, Prague (CZ)
||P. Hanč, K. Kotýnková, O. Vaněk, P. Pompach, P. Novák,
M. Holubová, P. Čeladová, K. Bezouška: Biochemical evidence for specific pairwise
interactions of mouse NKR-P1B/D:Clr-b receptors engaged in lectin-lectin interactions.
Faculty of Science, Charles University, Prague, and Institute of Microbiology of the ASCR,
v.v.i., Prague (CZ)
10.30-10.45 Coffee break
Chairpersons: Prof. A. Porgador (Israel), Dr. L. Rivoltini (Italy), Assist.
Prof. R. Špíšek (Czech Republic)
||J. Oujezdská, T. Vavrochová, A. Fišerová, D. Filipp:
Identification of Toll like receptors and immune related molecules as novel markers of
early embryonic phagocytes. Institute of Molecular Genetics of the ASCR, v.v.i., Prague,
and Faculty of Science, Charles University, Prague (CZ)
||J. Tomala, H. Chmelová, B. Říhová, M. Kovář:
Immunocomplexes of IL-2 and anti-IL-2 mAb S4B6 possess much stronger biological activity
than free IL-2 and also exert strong anti-tumor activity. Institute of Microbiology of the
ASCR, v.v.i., Prague (CZ)
||A. Brundu and S. Sopper: Influence of the infection with
simian immunodeficiency viruses (SIV) on inflammatory cytokines and neurotrophic factors
gene expression in the brain of rhesus macaques. German Primate Centre, Goettingen
(Germany), and University of Cagliari, Cagliari (Italy)
||Y. Sohrabi, H. Havelková, J. Vojtíšková, A. P. Stassen,
P. Demant, M. Lipoldová: Cypr4–Cypr7 control IFN-γ production by responder
cells in mixed lymphocyte reaction. Institute of Molecular Genetics of the ASCR, v.v.i.,
Prague (CZ), Department of Genetics and Cell Biology, Maastricht University, Maastricht
(The Netherlands), and Department of Molecular and Cellular Biology, Roswell Park Cancer
Institute, Buffalo, NY (USA)
11.50-14.00 Lunch and poster exhibition
Modulation of biological environments (by Magnesia)
Chairperson: Dr. L. Vannucci (Czech Republic)
||Prof. Helena Tlaskalová-Hogenová, Institute of Microbiology
of the ASCR, v.v.i., Prague (Czech Republic): "Microbiota, probiotics and prebiotics
in the modulation of the intestinal environment: potential tool for prevention of gut
inflammatory and neoplastic diseases"
Afternoon session: Brainstorming together
||General discussion on selected topics of interest emerged
during the meeting
The discussion will be open and informal, involving both speakers and
public of students and scientists
16.30-16.45 Conclusion of the workshop – final remarks
17.00-19.00 Farewell Buffet for all participants of the
workshop (cafeteria and garden of the Institute of Microbiology)