2017

Butler JE., Wertz N., Sinkora M.: Antibody Repertoire Development in Swine. Annu Rev Anim Biosci. 2017 Feb 8;5:255-279. doi: 10.1146/annurev-animal-022516-022818. PubMed PMID: 28199170. IF 4.708 Jourová L., Anzenbacher P., Lišková B., Matušková Z., Hermanová P., Hudcovic T., Kozáková H., Hrnčířová L., Anzenbacherová E.: Colonization by nonpathogenic bacteria alters mRNA expression of cytochromes P450 in originally germ-free mice. Folia Microbiol. (Praha). 2017 Mar 23. doi: 10.1007/s12223-017-0517-8. [Epub ahead of print] PubMed PMID: 28337589. IF 1.335 Musilova S., Modrackova N., Hermanova P., Hudcovic T., Svejstil R., Rada V., Tejnecky V. Bunesova V.: Synbiotic properties of human milk oligosaccharides and Bifidobacterium longum subsp. infantis in vitro and in humanized mice. Benef Microbes. 2017 Jan 24:1-9. doi: 10.3920/BM2016.013. IF 3.301 Schwarzer M., Srutkova D., Hermanova P., Leulier F., Kozakova H., Schabussova I.: Diet Matters: Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice. PLoS One. 2017 Jan 4;12(1):e0167786. doi: 10.1371/journal.pone.0167786. IF 3.057 Gorska S., Schwarzer M., Srutkova D., Hermanova P., Brzozowska E., Kozakova H., Gamian A.: Polysaccharides L900/2 and L900/3 isolated from Lactobacillus rhamnosus LOCK 0900 modulate allergic sensitization to ovalbumin in a mouse model. Microbial Biotechnol. 2017 Feb 6. doi: 10.1111/1751-7915.12606. IF 3.991 Górska S., Hermanova P., Ciekot J., Schwarzer M., Srutkova D., Brzozowska E., Kozakova H., Gamian A.: Chemical characterization and immunomodulatory properties of polysaccharides isolated from probiotic Lactobacillus casei LOCK 0919. Glycobiology. 2017 Mar 15;27(3):275-277. doi: 10.1093/glycob/cww107. IF 3.283 Sinkora M, Sinkorova J, Stepanova K.: Ig Light Chain Precedes Heavy Chain Gene Rearrangement during Development of B Cells in Swine. J. Immunol. 2017 Jan 9. pii: 1601035. doi: 10.4049/jimmunol.1601035 IF 4.985

2016

Butler J.E., Santiago-Mateo K., Wertz N., Sun X., Šinkora M., Francis D.: Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets. Dev Comp Immunol. 2016 Aug 3. pii: S0145-305X(16)30237-3. doi: 10.1016/j.dci.2016.07.020. IF 3.612 Górska S., Buda B., Brzozowska E., Schwarzer M., Šrůtková D., Kozáková H., Gamian A.: Screening and identification of Lactobacillus reactive protein for their potential as antigens in development of vaccine. BMC Microbiology, 2016, DOI 10.1186/s12866-016-0631-9. IF 3.251. Górska S., Hermanová P., Ciekot J., Schwarzer M., Šrůtková D., Brzozowska E., Kozáková H., Gamian A.: Chemical characterization and immunomodulatory properties of polysaccharides isolated from probiotic Lactobacillus casei LOCK 0919. Glycobiology. 2016 Sep;26(9):1014-1024. Epub 2016 Apr 21. PubMed PMID: 27102285; 2016. IF 3.283 Górska S., Dylus E., Rudawska A., Brzozowska E., Srutkova D., Schwarzer M., Razim A., Kozakova H., Gamian A.: Immunoreactive proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 identified by gnotobiotic mono-colonized mice sera, immune rabbit sera and nonimmune human sera. Frontier Microbiol. 2016 IF 4.165 Heissigerova J., Stangova P.S., Klímová A., Svozilková P., Hrnčíř T., Štěpánková R., Kverka M., Tlaskalová-Hogenová H., Forrester J.V.: The microbiota determines susceptibility to experimental autoimmune uveoretinitis. J Immunol Res. 2016;2016:5065703. doi: 10.1155/2016/5065703. Epub 2016 May 17. IF 2.812 Hucl T., Beneš M., Kočik M., Šplíchalová A., Malusková J., Krak M., Lánská V., Heczková M., Kieslichová E., Oliverius M., Špičák J.: Comparison of inflammatory response to transgastric and transcolonic NOTES. Gastroenterol Res Pract. 2016;2016:7320275. doi: 10.1155/2016/7320275. Epub 2016 Jun 14. IF 1.742 Kozakova H, Schwarzer M, Tuckova L, Srutkova D, Czarnowska E, Rosiak I, Hudcovic T, Schabussova I, Hermanova P, Zakostelska Z, Aleksandrzak-Piekarczyk T, Koryszewska-Baginska A, Tlaskalova-Hogenova H, Cukrowska B.: Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization. Cell Mol Immunol. 2016 Mar;13(2):251-62. doi: 10.1038/cmi.2015.09. IF 5.193 Kubelková K., Benuchová M., Kozáková H., Šinkora M., Krocová Z., Pejchal J., Macela A.: Gnotobiotic mouse model's contribution to understanding host-pathogen interactions. Cell Mol Life Sci. 73: 3961–3969, 2016. IF 5.694 Schwarzer M., Makki K., Storelli G., Machuca-Gayet I., Šrůtková D., Hermanová P., Martino M.E., Balmand S., Hudcovic T., Heddi A., Rieusset J., Kozáková H., Vidal H., Leulier F.: Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 351 (6275): 854-857, 2016. IF 33.611. Schwarzer M., Srutkova D., Hermanova P., Leulier F., Kozakova H., SchabussovaI.: Diet Matters: Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice. PLoS One. 2017 Jan 4;12(1):e0167786. doi: 10.1371/journal.pone.0167786. IF 3.057 Šinkora M., Butler J.E.: Progress in the use of swine in developmental immunology of B and T lymphocytes. Dev. Comp. Immunol. 58: 1-17, 2016. IF 3.612 Trachtová Š., Španová A., Horák D., Kozáková H., Rittich B.: Real-time polymerase chain reaction as a tool for evaluation of magnetic poly(glycidyl methacrylate)-based microspheres in molecular diagnostics. Curr Pharm Des.: 22(5), 639-646, 2016. IF 3.452 Villarino Romero R., Hasan S., Faé K, Holubová J., Geurtsen J., Schwarzer M., Wiertsema S., Osička R., Poolman J., Šebo P.: Bordetella pertussis filamentous hemagglutinin itself does not trigger anti-inflammatory interleukin-10 production by human dendritic cells. Int J Med Microbiol. 2016 Jan;306(1):38-47. doi: 10.1016/j.ijmm.2015.11.003. Epub 2015 Nov 30. PubMed PMID: 26699834. IF 3.614 Zákostelská Z., Málková J., Klimešová K., Rossmann P., Hornová M., Novosádová I., Stehlíková Z., Kostovčík M., Hudcovic T., Štepánková R., Jůzlová K., Hercogová J., Tlaskalová-Hogenová H., Kverka M.: Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response. PLoS One. 2016 Jul 19;11(7):e0159539. doi: 10.1371/journal.pone.0159539. eCollection 2016. IF 3.057

2015

Akgün J., Schabussova I., Schwarzer M., Kozáková H., Kundi M., Wiedermann U.: The role of alveolar epithelial type II-like cells in uptake of structurally different antigens and in polarisation of local immune responses. PLoS ONE 20;10(4):e0124777, 2015. doi: 10.1371/journal.pone.0124777. IF 3.234. Aleksandrzak-Piekarczyk T., Koryszewska-Bagińska A., Grynberga M., Nowak A, Cukrowska B., Kozakova H., Bardowski J.: Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring the spaCBA Pili Cluster in Lactobacillus casei LOCK 0919. Genome Biol Evol. 2015 Dec 3. pii: evv247, IF 4.23. Du Z., Hudcovic T., Mrazek J., Kozakova H., Srutkova D., Schwarzer M., Tlaskalova-Hogenova H., Kostovcik M., Kverka M.: Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis. Gut Pathog. 2015 Dec 21;7:32. doi: 10.1186/s13099-015-0080-2. eCollection 2015. PMID: 26697117, IF 2.28. Kozáková H., Schwarzer M., Tučková L., Šrůtková D., Czarnowska E., Rosiak I., Hudcovic T., Schabussova I., Hermanová P., Zákostelská Z., Aleksandrzak-Piekarczyk T., Koryszewska-Baginska A., Tlaskalová-Hogenová H., Cukrowska B.: Colonization of Germ-free Mice with the Mixture of Three Lactobacillus Strains Enhances the Integrity of Gut Mucosa and Ameliorates Allergic Sensitization to Main Birch Pollen Allergen Bet v 1. Cell. Molec. Immunol. 2015 Mar 23. doi: 10.1038/cmi.2015.09. IF 4.112. Potočková H., Šinkorová J., Kárová K., Šinkora M.: The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets. Developmental and Comparative Immunology 51: 99-107, 2015. ISSN 0145-305X. IF 2.815 Rossi O., Tanweer Khan M., Schwarzer M., Hudcovic T., Šrůtková D., Duncan S.H., Stolte E.H., Kozáková H., Flint H.J., Samsom J.N., Hermie J.M., Harmsen H.J.M., Wells J.M.: Faecalibacterium prausnitzii strain HTF-F and its extracellular polymeric matrix attenuate clinical parameters in DSS-induced colitis. PLos One 2015 Apr 24;10(4):e0123013. doi: 10.1371/journal.pone.0123013. eCollection 2015, IF 3.234. Šinkora M., Butler J.E.: Progress in the use of swine in developmental immunology of B and T lymphocytes. Dev. Comp. Immunol. doi: 10.1016/j.dci.2015.12.003. IF 2.815. Spanova A., Drab V., Turkova K., Spano M., Burdychova R., Sedo O., Srutkova D., Rada V., Rittich B.: Selection of potential probiotic Lactobacillus strains of human origin for use in dairy industry. Eur Food Res Technol, 2015. 241 (6):861-869. IF 1.559. Šrůtková D., Schwarzer M., Hudcovic T., Zákostelská Z., Dráb V., Španová A., Rittich B., Kozáková H., Schabussová I.: Bifidobacterium longum CCM 7952 promotes epithelial barrier function and prevents acute DSS-induced colitis in stricly strain-specific manner. PloS One, 2015, 10(7):e0134050. doi: 10.1371/journal.pone.0134050. Epub July 28, 2015. IF 3.234.

2014

Butler J.E., Lager K.M., Golde W., Faaberg K.S., Šinkora M., Loving C., Zhang Y.I.: Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunologic Research v. 59: 81 - 108, 2014. ISSN 0257-277X Górska S., Schwarzer M., Jachymek W., Šrůtková D., Brzozowska E., Kozáková H., Gamian A.: Distinct immunomodulation of bone marrow-derived dendritic cell responses to Lactobacillus plantarum WCSF1 by two different polysaccharides isolated from Lactobacillus rhamnosus. Applied and Environmental Microbiology 80: n. 20, 6506-6516, 2014. ISSN 1098-5336 Print 0099-2240 Hrnčířová L., Krejsek J., Šplíchal I., Hrnčíř T.: Crohn’s disease: a role of gut microbiota and Nod2 gene polymorphisms in disease pathogenesis. Acta Medica 57: n. 3, p. 89-96, 2014. Šinkora M., Šinkorová J.: New research methodologies used for the investigation of immune system in veterinary species. Educational Alternatives, v. 12: 58-65, 2014. ISSN 1313-2571 Šinkora M., Butler J.E. Lager K.M., Potočková H., Šinkorová J.: The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2. Veterinary Research 45: 1-18, 2014. ISSN 0928-4249 Šinkora M., Šinkorová J.: B cell lymphogenesis in swine is located in the bone marrow. The Journal of Immunology 193: 5023-5032, 2014 Šplíchalová A., Šplíchal I., Sonnenborn U., Rada V.: A modified MacConkey agar for selective enumeration of necrotoxigenic E. coli 055 and probiotic E. coli Nissle 1917. Journal of Microbiological Methods 104: 82-86, 2014. ISSN: 0167-7012 Tlaskalová-Hogenová H., Vannucci L., Klimešová K., Štěpánková R., Křižan J., Kverka M.: Microbiome and colorectal carcinoma insights from germ-free and conventional animal models. The Cancer Journal (The Journal of Principles and Practice of Oncology), DeVita V.T., Jr., Lawrence T.S., Rosenberg S.A., vol. 20: n. 3, p. 217-224, 2014.

2013

Butler J.E., Šinkora M.: The enigma of the lower gut-associated lymphoid tissue (GALT). J. Leukoc. Biol. 94: 2, 259-270, 2013 (IF 4,568) Kieslichová E., Ročeň M., Merta D., Kudla M., Šplíchal I., Čáp J., Viklický O., Gürlich R.: The effect of immunosuppression on manifestations of sepsis in an animal model of cecal ligation and puncture. Transplantation Proceedings 45: 770-777, 2013 (IF 0,952) Klimešová K., Kverka M., Zákostelská Z., Hudcovic T., Hrnčíř T., Štěpánková R., Rossmann P., Ridl J., Kostovcik M., Mrázek J., Kopečný J., Kobayashi K., Tlaskalová-Hogenová H.: Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice. Inflamm. Bowel Dis. 19: 6, 1266-1277, 2013 (IF 5,119) Schwarzer M., Šrůtková D., Schabussova I., Hudcovic T., Akgün J., Wiedermann U., Kozáková H.: Neonatal colonization of germ-free mice with Bifidobacterium longum prevents allergic sensitization to major birch pollen allergen Bet v 1. Vaccine 31: 5405-5412, 2013 (IF 3,492) Šinkora M., Štěpánová K., Šinkorová J.: Different anti-CD21 antibodies can be used to discriminate developmentally and functionally different subsets of B lymphocytes in circulation of pigs. Develop. Comp. Immunol. 39: 409-418, 2013 (IF 3,238) Štěpánová K., Šinkora M.: Porcine γδ T lymphocytes can be categorized into two functionally and developmentally distinct subsets according to expression of CD2 and level of TCR. J. Immunol. 190: 5, 2111 - 2120, 2013 (IF 5,520)

2012

Čapková J., Hrnčíř T., Kubatová A., Tlaskalová-Hogenová H.: Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice: The potential role of interleukin-10. BMC Musculoskelet. Disord. 13(1): 110. (IF 1.577) Goliáš J., Schwarzer M., Wallner M., Kverka M., Kozáková H., Šrůtková D., Klimešová K., Šotkovský P., Palová-Jelínková L., Ferreira F., Tučková L.: Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy. PLos One 7: 5, e37156, 1-10, 2012. (IF 4.411) Gürlich R., Kieslichová E., Merta D., Kudla M., Čáp J., Šplíchal I., Malušková J., Ročeň M.: Cékální ligace a punkce u miniprasat – metoda studia sepse. Čas. lék. českých 151 (5): 248 – 253, 2012. Hansen C.H.,F., Nielsen D.S., Kverka M, Zákostelská Z., Klimešová K., Hudcovic T., Tlaskalová-Hogenová H., Hansen A.K.: Patterns of early gut colonization shape future immune responses of the host. PLoS One 7: 3, e34043, 1-7, 2012. (IF 4.411) Hudcovic T., Kolínská J., Klepetář K., Štěpánková R., Řezanka T., Šrůtková D., Schwarzer M., Erban V., Du Z., Wells J.M., Hrnčíř T., Tlaskalová-Hogenová H., Kozáková H.: Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice. . Clin. Exp. Immunol. 167 (2): 356-365, 2012. (IF 3.009) Klimešová K., Kverka M., Zákostelská Z., Hudcovic T., Hrnčíř T., Štěpánková R., Rossmann P., Ridl J., Kostovcik M., Mrázek J., Kopečný J., Kobayashi K., Tlaskalová-Hogenová H.: Low microbial burden protects from colitis-associated cancer by Interleukin-1 receptor associated kinase-M dependent pathway. Inflamm. Bowel Dis., 2012. (IF 4.855) Mareš V., Stremeňová J., Lisá V., Kozáková H., Marek J., Syrůček M., Šoula O., Šedo A.: Compartment- and malignance-dependent up-regulation of γ-glutamyltranspeptidase and dipeptidyl- peptidase-IV activity in human brain gliomas. Histol. Histopathol. 27: 931-940, 2012. (IF 2.502) Muneta Y., Minagawa Y., Kusumoto M., Shinkai H., Uenishi H., Šplíchal I.: Development of allele-specific primer PCR for a swine TLR2 SNP and comparison of the frequency among several pig breeds of Japan and the Czech Republic J. Vet. Med. Science 74 (5): 553-559, 2012. (IF 0.722) Muneta Y., Minagawa Y., Kusumoto M., Shinkai H., Uenishi H., Šplíchal I.: Allele-specific primer polymerase chain reaction for a single nucleotide polymorphism (C1205T) of swine Toll-like receptor 5 and comparison of the allelic frequency among several pig breeds in Japan and the Czech Republic. Microbiol Immunol. 56: 385-391, 2012. Mar 16. doi: 10.1111/j.1348-0421.2012.00450.x. [Epub ahead of print] PubMed PMID: 22420886. (IF 1.227) Sun X., Wertz N., Lager K., Šinkora M., Štěpánová K., Tobin G., Butler J.E.: Antibody repertoire development in fetal and neonatal piglets. XXII. L rearrangement precedes k rearrangement during B-cell lymphogenesis in swine. Immunology 137: 149-159, 2012 (IF 3.321) Šinkora M., Štěpánová K., Šinkorová J.: Different anti-CD21 antibodies can be used to discriminate developmentally and functionally different subsets of B lymphocytes in circulation of pigs. Dev Comp Immunol. 2012 Nov 23. doi:pii: S0145-305X(12)00221-2.10.1016/j.dci.2012.10.010. [Epub ahead of print] PubMed PMID: 23178404. (IF 3.293) Šplíchalová A, Šplíchal I.: Local and systemic occurrences of HMGB1 in gnotobiotic piglets infected with E. coli O55 are related to bacterial translocation and inflammatory cytokines. Cytokine 60 (3):597-600, 2012. doi: 10.1016/j.cyto.2012.07.026. Epub 2012 Aug 15. PMID: 22902066 (IF 3.019) Štěpánová K., Šinkora M.: The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs. Develop. Compar. Immunol. 36: 728-740, 2012. (IF 3.293) von Schillde M.A., Hörmannsperger G., Weiher M., Alpert C.A., Hahne H., Bäuerl Ch., van Huynegem K., Steidler L., Hrnčíř T., Pérez-Martínez G., Kuster B., Haller D.: Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines. Cell Host Microbe 11: 4, 387-396, 2012. (IF 13.7)

2011

Biswas A, Wilmanski J, Forsman H, Hrncir T, Hao L, Tlaskalova-Hogenova H, Kobayashi KS.: Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine. Eur. J. Immunol. 2011 Jan;41(1):182-194 (2011). (IF 5,179) Cinova J., De Palma G., Stepankova R., Kofronova O., Kverka M., Sanz Y., Tuckova L.: Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats. PLoS One. 2011 Jan 13;6(1):e16169. PubMed PMID: 21249146 (IF 5.680) Kverka M., Zakostelská Z., Klimešová K., Sokol D., Hudcovic T., Hrnčíř T., Rossmann P., Mrázek J., Kopečný J., Verdu E.F., Tlaskalová-Hogenová H.: Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol. 2011 Feb;163(2):250-9. doi: 10.1111/j.1365-2249.2010.04286.x. Epub 2010 Nov 19. (IF 3.009) Schwarzer M., Repa A., Daniel C., Schabussova I., Hrnčíř T., Pot B., Štěpánková R., Hudcovic T., Pollak A., Tlaskalová-Hogenová H., Kozáková H.: Neonatal colonization of mice with Lactobacillus plantarum producing the aeroallergen Bet v 1 biases towards Th1 and T-regulatory responses upon systemic sensitization. Allergy 66: 368-375, 2011 (IF 6.380) Šplíchalová A., Trebichavský I., Rada V., Vlková E., Sonnenborn U., Šplíchal I.: Interference of Bifidobacterium choerinum or E. coli Nissle 1917 with Salmonella Typhimurium in gnotobiotic piglets correlates with cytokine patterns in blood and intestine. Clin. Exp. Immunol., 2011 Feb;163(2):242-9. doi: 10.1111/j.1365-2249.2010.04283.x. Epub 2010 Dec 13.2010. (IF 3.009) Šplíchalová A., Šplíchal I., Chmelařová P., Trebichavský I.: Alarmin HMGB1 is released in the small intestine of gnotobiotic piglets infected with enteric pathogens and its level in plasma reflects severity of sepsis. J. Clin. Immunol. 2011 Jun;31(3):488-97. Epub 2011 Jan 12. (IF 3.583) Šrůtková D., Španova A., Špano M., Kozaková H., Schwarzer M., Rittich B.: Efficiency of PCR-based methods in discriminating Bifidobacterium longum ssp. longum and Bifidobacterium longum ssp. infantis strains of human origin. J. Microbiol. Methods Oct;87(1):10-6. doi: 10.1016/j.mimet.2011.06.014. Epub 2011 Jul2. PubMed PMID: 21756944. (IF 2.427) Tlaskalová-Hogenová H., Štěpánková R., Kozáková H., Hudcovic T., Vannucci L., Tučková L., Rossmann P., Hrnčíř T., Kverka M., Zákostelská Z., Klimešová K., Přibylová J., Bártová J., Sanchez D., Fundová P., Borovská D., Šrůtková D., Zídek Z., Schwarzer M., Drastich P., Funda D.P.: Gut microbiota (commensal bacteria) and mucosal barrier in pathogenesis of inflammatory, autoimmune diseases and cancer: Contribution of germ-free and gnotobiotic models of human diseases. Cell. Mol. Immunol. 8:110-120, 2011. (IF 2.765)

2010

Cukrowska B., Rosiak I., Klewicka E., Motyl I., Schwarzer M., Libudzisz Z., Kozáková H.: Impact of heat-inactivated Lactobacillus casei and Lactobacillus paracasei strains on cytokine responses in whole blood cell cultures of children with atopic dermatitis. Folia Microbiol. 55: 3, 277-280, 2010. De Palma G., Cínová J., Štěpánková R., Tučková L., Sanz Y.: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the pro-inflammatory milieu of coeliac disease. J. Leukocyte Biology 87: 765-778, 5, 2010. Holtmeier W., Gille J., Zeuzem S., Šinkora M.: Distribution and development of the postnatal murine Vd1 T-cell receptor repertoire. Immunology 2010, Oct;131(2):192-201. doi: 10.1111/j.1365-2567.2010.03290.x. PubMed PMID: 20465568; PubMed Central PMCID: PMC2967265. Kolínská J., Zákostelecká M., Schwarzer M., Štěpánková R., Hudcovic T., Kozáková H.: Effect of nonpathogenic Escherichia coli monoassociation on small intestinal brush-border glycoconjugate moieties and cytokine production after colonization in ex-germ-free rats and piglets. Int. J. Interferon, Cytokine, Mediator Res. 2: 73-84, 2010. Rada V., Šplíchal I., Rocková S., Grmanová M., Vlková E.: Susceptibility of bifidobacteria to lysozyme as a possible selection criterion for probiotic bifidobacterial strains. Biotechnol. Lett. 32: 451-455, 2010. Štěpánková R., Tonar Z., Bártová J., Nedorost L., Rossman P., Poledne R., Schwarzer M., Tlaskalová-Hogenová H.: Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet. J. Atheroscler. Thromb. 17: 8, 2010. Trebichavský I., Šplíchal I., Šplíchalová A.: Innate immune response in the gut against Salmonella – review. Folia Microbiol. 55: 3, 295-300, 2010.

2009

Butler J.E., Lager K.M., Šplíchal I., Francis D., Kacskovics I., Šinkora M., Wertz N., Sun J., Zhao Y., Brown W.R., DeWald R., Dierks S., Muyldermanns S., Lunney J.K., McCray P., Rogers C., Welsch M., Navarro P., Klobasa F., Habe F., Ramsoondar J.: Piglet models in studies on antibody repertoire development. Vet. Immunol. Immunopathol. 128: 147-170, 2009. Butler J.E., Zhao Y., Šinkora M., Wertz N., Kacskovics I.: Immunoglobulins, antibody repertoire and B cell development. Dev. Comp. Immunol. 33: 321-333, 2009. Cukrowska B., Motyl I., Kozáková H., Schwarzer M., Górecki RK., Klewicka E., Slizewska K., Libudzisz Z.: Probiotic Lactobacillus strains: in vitro and in vivo studies. Folia Microbiol. 54: 533-537, 2009. Hudcovic, T., Kozakova H., Kolinska, J., Stepankova, R., Hrncir, T., Tlaskalova-Hogenova, H.: Monocolonization with Bacteroides ovatus protects immunodeficient SCID mice from mortality in chronic intestinal inflammation caused by long-lasting dextran sodium sulfate treatment. Physiol. Res. 58: 101-110, 2009. Petnicki-Ocwieja T., Hrncir T., Liua Y.-J., Biswasa A., Hudcovic T., Tlaskalova-Hogenova H., Kobayashia K.S.: Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A. 2009 Sep15; 106(37):15813-8. doi: 10.1073/pnas.0907722106. Epub 2009 Sep 1. PubMed PMID: 19805227; PubMed Central PMCID: PMC2747201. Šinkora M., Butler J.E.: The ontogeny of the porcine immune system. Dev. Comp. Immunol. 33: 273-283, 2009. Trebichavský I., Rada V., Šplíchalová A., Šplíchal I.: Cross-talk of human gut with bifidobacteria. Nutr. Rev. 67: 77-82, 2009. Vannucci L., Štěpánková R., Grobárová V., Kozáková H., Rossmann P., Klimešová K., Benson V., Šíma P., Fišerová A., Tlaskalová-Hogenová H.: Colorectal carcinoma: importance of colonic environment for anti-cancer response and systemic immunity. J. Immunotoxicol. 6: 217-226, 2009.

2008

Hrnčíř T., Štěpánková R., Kozáková H., Hudcovic T., Tlaskalová-Hogenová H.: Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice. BMC Immunology 9: 65-00, 2008. Kolínská J., Lisá V., Clark J., Kozáková H., Zákostelecká M., Khailova L., Šinkora M., Kitanovičová A., Dvorak B.: Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: Effect of TNF-α and IFN-γ treatment. J. Interferon & Cytokine Res. 28: 287-296, 2008. Repa A. and Kozáková H. (Both authors contributed equally to the work), Hudcovic T., Štěpanková R., Hrnčíř T., Tlaskalová-Hogenová H., Pollak A., Wiedermann U.: Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora. Immunol. Lett. 117: 50-56, 2008. Šinkorová Z., Čapková J., Niederlová J., Štěpánková R., Šinkora J.: Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2(k)) male mice. Hum. Immunol. 69: 845-850, 2008. Vannucci L., Štěpánková R., Kozáková H., Fišerová A., Rossmann P., Tlaskalová-Hogenová H.: Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affects the systemic immunity. Int. J. Oncology 32: 609-617, 2008.

2007

Butler, J.E., Šinkora, M.: The isolator piglet: a model for studying the development of adaptive immunity. Immunol. Res. 39: 1-3, 33-51, 2007. Hudcovic T., Štěpánková R., Kozáková R., Hrnčíř T., Tlaskalová-Hogenová H.: Effects of monocolonization with Escherichia coli strains 06K13 and Nissle 1917 on the development of experimentally induced acute and chronic intestinal inflammation in germ-free immunocompetent and immunodeficient mice. Folia Microbiol. 52: 6, 618-626, 2007. Šplíchal I., Rychlík I., Gregorová D., Šebková A.: Trebichavský I., Šplíchalová A., Muneta Y., Mori Y.: Susceptibility of germ-free pigs to challenge with protease mutants of Salmonella enterica serovar Typhimurium. Immunobiology 212: 577-582, 2007. Štěpánková R., Powrie F., Kofroňová O., Kozáková H., Hudcovic T., Hrnčíř T., Uhlig H., Read S., Řeháková Z., Benada O., Heczko P., Strus M., Bland P.,Tlaskalová-Hogenová H.: Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. Inflamm. Bowel. Dis. 13: 10, 1202-1211, 2007. Tlaskalová-Hogenová H., Štěpánková R., Tučková L., Palová-Jelínková L., Kozáková H., Hudcovic T., Sanchez D., Frolová L., Cinová J., Pecharová B.: Gluten and chronic diseases: Inflammatory activity of gluten. „Inflammation and Infection. The Golden Triangle: Food – Microflora – Host Defense“. P.J.Heidt, Z.Midtvedt, V.Rusch, D. van der Waaij (eds.). Old Herborn University Seminar Monography 2007. Probert C.S., Williams A.M., Štěpánková R., Tlaskalová-Hogenová H., Phillips A., Bland P.W.: The effect of weaning on the clonality of alphabeta T-cell receptor T cells in the intestine of GF and SPC mice. Dev. Comp. Immunol. 31: 606-617, 2007. Butler J.E., Lemke C.D., Weber P., Šinkora M., Lager K.M.: Antibody repertoire development in fetal and neonatal piglets: XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome. J. Immunol. 178: 6320-6331, 2007. Šinkora M., Šinkorová J., Cimburek Z., Holtmeier W.: Two groups of porcine TCRgammadelta+ thymocytes behave and diverge differently. J. Immunol. 178: 711-719, 2007.

2006

Williams AM., Probert CS., Štěpánková R., Tlaskalová-Hogenová H., Phillips A., Bland PW.: Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse. Immunology 119: 470-478, 2006. Uhlig HH., McKenzie BS., Hue S., Thompson C., Joyce-Shaikh B., Štěpánková R., Robinson N., Buonocore S., Tlaskalová-Hogenová H., Cua DJ., Pwrie F.: Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity: 309-318, 2006. Butler J.E., Sun J., Wertz N., Šinkora M.: Antibody repertoire development in swine. Developmental and Comparativ. Immunol. 30: 199-221, 2006. Butler J.E., Šinkora M., Wertz N., Holtmeier W., Lemke C.D.: Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology. Vet. Res. 37: 417-441, 2006. Kozáková H., Kolínská J., Lojda Z., Řeháková Z., Šinkora J., Zákostelecká M., Šplíchal I., Tlaskalová-Hogenová H.: Effect of bacterial monoassociation on brush-border enzyme activities in ex-germ-free piglets: comparison of commensal and pathogenic Escherichia coli strains. Microbes Infect.: 2629-2639, 2006.

2005

Cardona M.E., Kozáková H., Collinder E., Persson A.K., Midtvedt T., Norin E.: Biochemical intestinal parameters in germ-free minipigs and rats and in ex-germfree minipigs and rats monoassociated with Escherichia coli. J. Vet. Med. A Physiol. Pathol. Clin. Med. 52: 109-113, 2005. Šinkora M., Šinkorová J., Holtmeier W.: Development of γδ thymocyte subsets during prenatal and postnatal ontogeny. Immunology, 115: 544-555, 2005. Šinkora M., Butler J.E., Holtmeier W., Šinkorová J.: Lymphocyte development in fetal piglets: Facts and surprises. Vet. Immunol. Immunopathol. 108: 177-184, 2005. Šplíchal I., Trebichavký I., Šplíchalová A, Barrow P. A.: Protection of gnotobiotic pigs against Salmonella enterica serotype Typhimurium by rough mutant of the same serotype is accompanied by the change of local and systemic cytokine response. Vet. Immunol. Immunopathol. 103, 155-161, 2005. Šplíchal I., Fagerhol M.K., Trebichavský I., Šplíchalová A., Schulze J.: The effect of intestinal colonization of germ-free pigs with Escherichia coli on calprotectin levels in plasma, intestinal and bronchoalveolar lavages. Immunobiology 209: 681-687, 2005. Šplíchalová A., Trebichavský I., Muneta Y., Mori Y., Šplíchal I.: Effect of bacterial virulence on IL-18 expression in the amnion infected with Escherichia coli. Amer. J. Reprod. Immunol. (AJRI) 53: 255-260, 2005. Tlaskalová-Hogenová H., Tučková L., Městecký J., Kolínská J., Rossmann P., Štěpánková R., Kozáková H., Hudcovic T., Hrnčíř T., Frolová L., Kverka M.: Interaction of mucosal microbiota with the innate immune system. Scand. J. of Immunol. 62 (Suppl. 1): 106-113, 2005. Tlaskalová-Hogenová H., Tučková L., Štěpánková R., Hudcovic T., Palová-Jelínková L., Kozáková H., Rossmann P., Sanchez D., Cinová J., Hrnčíř T., Kverka M., Frolová L., Uhlig H., Powrie F., Bland P.: Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Ann. N.Y.Acad. Sci. 1051: 787-798, 2005.

2004

Čapková J., Štěpánková R., Hudcovic T., Šinkora J., Řeháková Z.: Experimental colitis does not increase the prevalence of ANKENT, a spontaneous joint disease in mice. Folia Microbiol. 49: 745-750, 2004. Hanniffy S., Wiedermann U., Repa A., Mercenier A., Daniel C., Fioramonti J., Tlaskalová H., Kozáková H., Israelsen H., Madsen S., Vrang A., Hols P., Delcour J., Bron P., Kleerebezem M., Wells J.: Potential and opportunities for use of recombinant lactic acid bacteria in human health. Laskin A.I., Bennett J.W., Gadd G.M. (eds.), Elsevier Acad. Press., USA. Adv. Appl. Microbiol. 56: 1-64, 2004. Holtmeir W., Geisel W., Bernert K., Butler JE., Sinkora M., Rehakova Z., Sinkora J., Caspary WF.: Prenatal development of the porcine TCR delta repertoaire: dominant expression on an invariant T cell receptor Vdelta3-Jdelta3 chain. Eur. J. Immunol. 34: 1941-1949, 2004. Stříž I., Trebichavský I.: Calprotectin - a pleiotropic molecule in acute and chronic inflammation. Physiol. Res. 53: 245-253, 2004. Šplíchalová A., Šplíchal I., Trebichavský I., Hojná H.: Expression of inflammatory markers in pig amnion after intraamniotic infection with nonpathogenic or enteropathogenic Escherichia coli. Folia Microbiol. 49: 751-756, 2004. Tlaskalova-Hogenova H., Stepankova R, Hudcovic T, Tuckova L., Cukrowska B., Lodinova-Zadnikova R., Kozakova H., Rossman P., Bartova J., Sokol D., Funda DP., Borovska D., Rehakova Z., Sinkora J., Hofman J., Drastich P., Kokesova A.: Commensal bacteria (normal microflora), mucosal immunity and chronic inflamatory and autoimmune diseases. Immunol. Lett. 93:97-108, 2004. Šinkora M., Šinkorová J.: Development of B thymocytes and γδ T cells during prenatal and postnatal ontogeny in pigs. Immunology 2004, Medimond S.r.1., 12th Int. Congr. of Immunol. And 4th Annual Conf. of FOCIS, 373-379, 2004.

2003

Trebichavsky I., Splichal I., Splichalova A., Muneta Y., Mori Y.: Systematic and local cytokine response of young piglets to oral infection with Salmonela enterica serotype Typhimurium. Folia Microbiol.48: 403-407, 2003. Dvorak B., Halpern M.D., Holubec H., Dvorakova K., Dominguez J.A.,Williams CS., Meza Y.G., Kozakova H., McCuskey R.S.: Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model. Pediatr. Res.53: 1-8, 2003. Faldyna M., Sinkora J., Knotigova P., Rehakova Z., Moravkova A., Toman M.: Flow cytometric analysis of bone marrow leukocytes in neonatal dogs. Vet. Immunol. Immunopathol. 95: 165-176, 2003. Kozakova H., Hanson L.A., Stepankova R., Kahu H., Dahlgren U.I., Wiedermann U.: Vitamin A deficiency leads to severe functional disturbance of the intestinal epithelium enzymes associated with diarrhea and increased bacterial translocation in gnotobiotic rats. Microbes and Infections 5: 405-411, 2003. Mares V., Lisa V., Malik R., Kozakova H., Sedo A.: Cisplatin induced gammaglutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. Histology Histopatology 18: 687-693, 2003. Sinkora M., Sun J., Sinkorova J., Christenson R.K., Ford S.P., Butler J.E.: Antibody repertoire development in fetal and neonatal piglets. VI. B cell lymphogenesis occurs at multiple sites with differences in the frequency of in-frame rearrangements. The Journal of Immunology 170: 1781-1788, 2003. Stepankova R., Kofronova O., Tuckova L., Kozakova H., Cebra J.J.,Tlaskalova-Hogenova H.: Experimentally induced gluten enteropathy and protective effect of epidermal growth factor in artificially fed neonatal rats. J. Pediatr. Gastroent. Nutr. 36: 96-104, 2003. Tlaskalová-Hogenová H., Štěpánková R., Sokol D., Rossmann P., Cukrowska B., Hudcovic T., Tučková L., Kozáková H., Řeháková Z., Hrnčíř T., Drastich P., Frolová L., Powrie F., Uhlig H., Bland P.: Mucosal immunity, intestinal microflora and inflammatory bowel disease. Proceed. of FALK Symp. 135 "Immunological Disease of Liver and Gut", Prague, Sept. 12-13, 2003. Kluwer Acad. Publ., 152-167, 2003.

2002

Butler J.E., Sun J., Weber P., Ford S.P., Rehakova Z., Sinkora J., Francis D., Lager K.: Switch recombination in fetal porcine thymus is uncoupled from somatic mutation. Vet. Immunol. Immunopathol. 87: 307-319, 2002. Butler J.E., Weber P., Sinkora M., Baker D., Schoenherr A., Mayer B., Francis D.: Antibody repertoire development in fetal and neonatal piglets. VIII. Colonization is required for newborn piglets to make serum antibodies to T-dependent and type 2 T-independent antigens. The Journal of Immunology 169: n. 12, 6822-6830, 2002. Collinder E., Cardona M.E., Kozakova H., Norin E., Stern S., Midtvedt T.: Biochemical intestinal parameters in pigs reared outdoors and indoors, and in germ-free pigs. J. Vet. Med., S.A 49: 203-209, 2002. Dvorak B., Halpern M.D., Holubec H., Williams C.S., McWilliam D.L., Dominguez J.A., Stepankova R., Payne C.M., McCuskey R.S.: Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Amer. J. Physiol., sec.Gastroint. Liv. Physiol. 282: 156-164, 2002. Kozakova H., Mlckova P., Kolinska J., Cechova D., Stepankova R., Rehakova Z., Prokesova L.: Differential effect of Bacillus firmus on immune response and enterocyte brush-border enzyme levels in BALB/c and B10.BR mice. Folia Microbiol. 47: n.6, 759-765, 2002. Sinkora J., Kolinska J., Rehakova Z., Cerny J., Doubravska L.: Binding of the Galanthus nivalis agglutinin to thymocytes reveals alterations in surface glycosylation during T cell development. Scand. J. Immunol. 55: 196-203, 2002. Sinkora J., Rehakova Z., Sinkora M., Cukrowska B., Tlaskalova-Hogenova H.: Early development of immune system in pigs. Vet. Immunol. Immunopathol. 87: 301-306, 2002. Sinkora M., Sinkorova J., Butler J.E.: B cell development and VDJ rearrangement in the fetal pig. Vet. Immunol. Immunopathol. 87: 341-346, 2002. Tlaskalova-Hogenova H., Tuckova L., Lodinova-Zadnikova R., Stepankova R., Cukrowska B., Funda D.P., Striz I., Kozakova H., Trebichavsky I., Sokol D., Rehakova Z., Sinkora J., Fundova P., Horakova D., Jelinkova L., Sanchez D.: Mucosal immunity: Its role in defense and allergy. Int. Arch. Allergy Immunol. 128: 77-89, 2002. Toman M., Faldyna M., Knotigova P., Pokorova D., Sinkora J.: Postnatal development of leukocyte subset composition and activity in dogs. Vet. Immunol. Immunopathol. 87: 321-326, 2002.

2001

Boersma W.J.A., Zwart R.J., Sinkora J., Rehakova Z., Haverson K., Bianchi A.T.J.: Summary of workshop findings for porcine B-cell markers. Vet. Immunol. Immunopathol. 80: n.1-2, 63-78, 2001. Butler J.E., Sun J., Weber P., Ford S.P., Rehakova Z., Sinkora J., Lager K.: Antibody repertoire development in fetal and neonatal piglets. IV. Switch Recombination, primarily in fetal thymus, occurs independent of environmental Antigen and is only weakly associated with repertoire diversification. The Journal of Immunology 167: n. 6, 3239-3249, 2001. Cukrowska B., Kozakova H., Rehakova Z., Sinkora J., Tlaskalova-Hogenova H.: Specific antibody and immunoglobulin responses after intestinal colonization of germ-free piglets with nonpathogenic Escherichia coli 086. Immunobiol. 204: 425-433, 2001. Haverson K., Saalmuller A., Alvarez B., Alonso F., Bailey. M., Bianchi A.T.J., Boersma W.J.A., Chen Z., Davis W.C., Dominguez J., Engelhardt H., Ezquerra A., Grosmaire L.S., Hamilton M.J., Hollemweguer E., Huang C.A., Khanna K.V., Kuebart G., Lackovic G., Ledbetter J.A., Lee R., Llanes D., Lunney J.K., McCullough K.C., Molitor T., Nielsen J., Niewold T.A., Pescovitz M.D., Perez de la Lastra J., Rehakova Z., Salmon H., Schnitzlein W.M., Seebach J., Simon A., Sinkora J., Sinkora M., Stokes C.R., Summerfield A., Sver L., Thacker E., Valpotic I., Yang H., Zuckermann F.A., Zwart R.: Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens. Vet. Immunol. Immunopathol. 80: n.1-2, 5-23, 2001. Hudcovic T., Stepankova R., Cebra J., Tlaskalova-Hogenova H.: The role of microflora in the development of intestinal inflammation: Acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immuno- competent and immunodeficient mice. Folia Microbiol. 46: 6, 565-572, 2001. Kozakova H., Rehakova Z., Kolinska J.: Bifidocacterium bifidum monoassociation of gnotobiotic mice: Effect on enterocyte brush- border enzymes. Folia Microbiol. 46: 6, 573-576, 2001. Singh B., Read S., Asseman C., Malmstrom V., Mottet Ch., Stephens L.A., Stepankova R., Tlaskalova H., Powrie F.: Control of intestinal inflammation by regulatory T cells. Immunol. Rew. 182: 190-200, 2001. Sinkora J., Rehakova Z., Samankova L., Haverson K., Butler J.E., Zwart R., Boersma W.: Characterization of monoclonal antibodies recognizing immunoglobulin kappa and lambda chains in pigs by flow cytometry. Vet. Immunol. Immunopathol. 80: n.1-2, 79-91, 2001. Sinkora J., Rehakova Z., Haverson K., Sinkora M., Dominguez J., Huang Ch.A.: Monoclonal antibodies putatively recognising activation and differentiation antigens. Vet. Immunol. Immunopathol. 80: n. 1-2, 143-164, 2001. Thacker E., Summerfield A., McCullough K., Ezquerra A., Dominguez J., Alonso F., Lunney J., Sinkora J., Haverson K.: Summary of workshop findings for porcine myelomonocytic markers. Vet. Immunol. Immunopathol. 80: n. 1-2, 93-109, 2001. Wroblewski S., Rihova B., Rossmann P., Hudcovic T., Rehakova Z., Kopeckova P., Kopecek J.: The influence of a colonic microbiota on HPMA copolymer lectin conjugates Binding in rodent intestine. J. Drug Target. 9: n.2, 85-94, 2001. Zuckermann F.A., Schnitzlein W.M., Thacker E., Sinkora J., Haverson K.: Characterization of monoclonal antibodies assigned to the CD45 subgroup of the Third International Swine CD Workshop. Vet. Immunol. Immunopathol. 80: n. 1-2, 165-174, 2001.

2000

Butler J.E., Weber P., Sinkora M., Sun J., Ford S.J., Christenson R.K.: Antibody repertoire development in fetal and neonatal piglets. II. Characterization of heavy chain complementarity-determining region 3 diversity in the developing fetus. The Journal of Immunology 165: 6999 - 7010, 2000. Drbal K., Cerny J., Angelisova P., Hilgert I., Cebecauer M., Sinkora J., Horejsi V.: Cdw149 antibodies recognize a clustered subset of CD47 molecules associated with cytoplasmic signaling molecules. Tissue Antigens 56 (3): 258-267, 2000. Kozakova H., Stepankova R., Tuckova L., Sinkora M., Jelinkova L.,Tlaskalova-Hogenova H.: Humoral and cellular immune responses in gluten-treated suckling or hand-fed rats. Physiol. Res. 49: 665-672, 2000. Rehakova Z., Capkova J., Stepankova R., Sinkora J., Louzecka A., Ivanyi P., Weinreich S.: Germ-free mice do not develop ankylosing entesopathy, a spontaneous joint disease. Human Immunol.61: 6, 555-558, 2000. Sinkora M., Sinkora J., Rehakova Z., Butler J.E.: Early ontogeny of thymocytes in pigs: sequential colonization of the thymus by T-cell progenitors. J. Immunol. 165: 1832-1839, 2000. Sinkora M., Sun J., Butler J.E.: Antibody repertoire development in fetal and neonatal piglets. V. VDJ gene chimeras resembling gene conversion products are generated at high frequency by PCR in vitro. Molec. Immunol. 37: 1025 - 1034, 2000.