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SHORT COMMUNICATION
The Effect of Triiodothyronine
on Changes of Membrane Fluidity in Regenerating Rat Liver
Z. DRAHOTA1, H.
RAUCHOVÁ1, V. SEDLÁK2, J. KOČÍ2,
Z. ČERVINKOVÁ2
1Institute of Physiology, Academy of Sciences of
the Czech Republic, Prague and 2Department of Physiology,
Medical Faculty, Charles University, Hradec Králové, Czech
Republic
Received October 5, 1998
Accepted December 3, 1998
Summary
The increase of the membrane fluidity during the early phase of
liver regeneration after partial hepatectomy was described in
literature in plasma membrane and in microsomes. We found
similar changes also in isolated mitochondria and in crude total
membrane fraction of the liver homogenate. The administration of
triiodothyronine to rats before partial hepatectomy diminished
the increase of the membrane fluidity in the regenerating liver
by 50 %. Triiodothyronine effect is explained by hormonal
modification of lipid metabolism in the regenerating liver.
Key words
Liver regeneration · Membrane fluidity · Triiodothyronine ·
Mitochondria
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