SHORT COMMUNICATION
Reciprocal Adaptive Response
of Human Peripheral Lymphocytes Induced by Bleomycine or Gamma
Rays
I. Kalina, P. Brezáni, V. Habalová, A. Kohút1, E.
Biroš, G. Némethová, J. Šalagovič
Department of Medical Biology and 1Department of
Pharmacology, Medical Faculty, P.J. Šafárik University, Košice,
Slovak Republic
Received July 10, 1998
Accepted January 26, 1999
Summary
The adaptive response and reciprocal adaptive response induced
in vitro by exposure to low doses of gamma rays (0.05 Gy) or
bleomycin (0.05 µ g/ml) in human peripheral blood lymphocytes
were assessed by the frequency of chromosome aberrations. Gamma
rays (1.5 Gy) or bleomycin (1.5 µ g/ml) were used as the
challenge doses. In the experiments, blood samples from 5
healthy donors were investigated. It has been found that low
doses of bleomycin and gamma rays induced a reciprocal adaptive
response to high doses of gamma rays or bleomycin. Moreover, the
results confirmed that the adaptive response did not correlate
with the radiosensitivity of the peripheral blood lymphocytes.
Key words
Adaptive response · Reciprocal adaptive response · Gamma rays ·
Bleomycin · Chromosome aberration
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