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Association Analysis of 24-h
Blood Pressure Records with I/D ACE Gene Polymorphism and ABO
Blood Group System
A. VAŠKU, M. SOUČEK1,
D. HÁJEK, L. HOLLÁ, V. ZNOJIL, J. VÁCHA
Institute of Pathological Physiology, Medical
Faculty of Masaryk University and 1First Department
of Internal Medicine, St. Ann’s Faculty Hospital, Brno, Czech
Republic
Received February 24, 1998
Accepted September 14, 1998
Summary
The purpose of this study was to analyze the association between
24-h blood pressure parameters, insertion/deletion polymorphism
of the angiotensin I converting enzyme gene and the ABO blood
group system in a sample of the general Czech population.
Fourteen parameters describing the 24-h blood pressure readings
were obtained by analyzing blood pressure records in 243
volunteers, 119 men and 124 women. These parameters were
adjusted for sex and body mass index (BMI) by means of multiple
regression test. All subjects were genotyped for the
insertion/deletion polymorphism of angiotensin I converting
enzyme (I/D ACE) gene and routinely examined for the blood group
phenotype in the ABO system. An association was found between
the interaction of I/D ACE gene polymorphism and ABO blood group
system on the one hand and mean values of systolic (p=0.016) or
mean arterial (p=0.027) blood pressures and the phase shift of
24-h BP rhythm (p=0.036) on the other hand. Among three I/D ACE
variants the DD genotype was associated with the highest values
of mean blood pressure in blood group A and AB carriers. The
same genotype was associated with the lowest blood pressures in
blood group B and O carriers. In subjects with the DD genotype,
the earlier daily position of the maximum of 24-h BP rhythm was
found in blood group B, AB and O carriers. On the contrary,
blood group A was associated with the latest position of maximum
of the 24-h BP rhythm in the DD genotypes.
Key words
Circadian blood pressure rhythm · I/D ACE polymorphism · ABO
blood group system · Sex · Body mass index
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