Alkaline Phosphatase Activity of Duodenal Enterocytes After Neonatal
Administration of Monosodium Glutamate to Rats
Š. MOZEŠ, Ľ. LENHARDT1,
A. MARTINKOVÁ
Institute of Animal Physiology, Slovak Academy of Sciences and 1Department
of Pathology, Veterinary University, Košice, Slovak Republic
Received April 16, 1999
Accepted July 12, 1999
Summary
In the present work neonatal male and female Wistar rats were
treated intraperitoneally with monosodium glutamate (MSG 2 mg/kg b.w.) or saline
(controls) daily for 4 day after birth. At the age of 30 and 80 days, the
alkaline phosphatase activity (AP) in the brush border of individual enterocytes,
the body fat content and Lee´s index of obesity were analyzed. Microdensitometrical quantification of AP was significantly increased on day 30
in males (P<0.01) and on day 80 in MSG-treated male and female rats
(P<0.001) as compared to the controls. MSG administration also increased the
body fat weight and the obesity index significantly (P<0.001) in 80-day-old
animals, but was without any significant effect on their food intake. Our
results showed that a) neonatal MSG-treatment may significantly change the
intestinal function and b) the investigation of the intestinal enzyme activities
may be important in further studies on MSG-induced and other forms of obesity.
Key words
Alkaline phosphatase activity · Duodenal enterocytes · Monosodium glutamate ·
Obesity · Rat
Reprint requests
Dr. Š. Mozeš, Institute of Animal Physiology, Slovak
Academy of Sciences, Šoltesovej 4, 040 01 Košice, Slovak Republic. E mail: mozes@mail.saske.sk,
martink@mail.saske.sk
|