Baroreflex Control of Heart Rate in Young and Adult Salt Hypertensive Inbred
Dahl Rats
J. NEDVÍDEK, J. ZICHA
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague,
Czech Republic
Received February 21, 2000
Accepted March 27, 2000
Summary
Baroreflex control of heart rate was studied in inbred
salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) Dahl rats that were subjected
to chronic dietary sodium chloride loading (for 4 weeks) either in youth or
only in adulthood, i.e. from the age of 4 or 12 weeks. Using phenylephrine
administration to pentobarbital-anesthetized male rats we have demonstrated the
decreased baroreflex sensitivity (lower slope for reflex bradycardia) in young prehypertensive SS/Jr rats fed a low-salt diet as compared to age-matched SR/Jr
animals. High salt intake further suppressed baroreflex sensitivity in young SS/Jr
but not in SR/Jr rats. Baroreflex sensitivity decreased with age in SR/Jr rats,
whereas it increased in SS/Jr rats fed a low-salt diet. Thus at the age of 16
weeks baroreflex sensitivity was much higher in SS/Jr than in SR/Jr animals.
High salt intake lowered baroreflex sensitivity even in adult SS/Jr rats without
affecting it in adult SR/Jr rats. Nevertheless, baroreflex sensitivity was
significantly lower in young SS/Jr rats with a severe salt hypertension
than in adult ones with a moderate blood pressure elevation. It is concluded
that the alterations of baroreflex sensitivity in young inbred SS/Jr rats
(including the response to high salt intake) are similar to those described
earlier for outbred salt-sensitive Dahl rats. We have, however, disclosed
contrasting age-dependent changes of baroreflex sensitivity in both inbred substrains of Dahl rats.
Key words
Baroreflex sensitivity · Heart
rate · Blood pressure ·
Age · Salt intake · Phenylephrine · Inbred Dahl rats
Reprint requests
Dr. Josef Zicha, Institute of Physiology, Academy of Sciences
of the Czech Republic, Videnska 1083, CZ-142 20 Prague 4, Czech Republic.
e-mail zicha@biomed.cas.cz.
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