Terguride
Attenuates Prolactin Levels and Ameliorates
Insulin Sensitivity and Insulin Binding in Obese
Spontaneously Hypertensive Rats
V.
GOLDA†, M. FICKOVÁ1, L.
PINTEROVÁ1, J.
JURČOVIČOVÁ1, L. MACHO1,
Š. ZÓRAD1*
Institute
of Experimental Neurosurgery, Hradec Králové,
Czech Republic and 1Institute
of Experimental Endocrinology, Bratislava, Slovak
Republic
† deceased
Received
March 17, 2000
Accepted July 17, 2000
Summary
Glucose tolerance, serum insulin, insulin
receptors in epididymal fat tissue, circulating
total cholesterol and triglyceride concentrations
as well as serum prolactin were studied in obese
and lean spontaneously hypertensive rats (SHR) of
both sexes. Obese animals displayed insulin
resistance and elevated insulin and triglyceride
concentrations. Moreover, in obese rats the
increased mass of epididymal fat tissue was
accompanied with decreased capacity of high
affinity binding sites of insulin receptors in
the tissue plasma membranes. Terguride treatment
lowered prolactin serum levels which was
accompanied by ameliorated insulin sensitivity in
obese animals of both sexes. In addition,
terguride treatment decreased serum insulin and
triglyceride concentrations in obese females and
at the same time enhanced the affinity of high
affinity insulin binding sites. Our results show
that obesity in SHR is associated with a
decreased capacity of insulin receptors and that
prolactin may play a role in obesity-induced
insulin resistance, particularly in female rats.
Key
words
Prolactin · Obese SHR · Insulin
binding · Fat tissue · Insulin sensitivity
Reprint requests
Š. Zórad Ph.D., Metabolic Regulation
Research Group, Institute of Experimental
Endocrinology, Slovak Academy of Sciences,
Vlárska 3, 833 06 Bratislava, Slovakia. Fax:
00421-7-54774247. E-mail: ueenstef@savba.savba.sk
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