Volume 50: 215-219, 2001

Excitability Changes of Cortical Neurons during the Postnatal Period in Rats Exposed to Prenatal Hypobaric Hypoxia

D. MAREŠOVÁ, I. VALKOUNOVÁ, K. JANDOVÁ, J. BORTELOVÁ, S. TROJAN

Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic

Received June 14, 2000
Accepted August 29, 2000

Summary
Pregnant rats were exposed to intermittent hypobaric hypoxia (at a simulated altitude of 7000 m or 5000 m) and the excitability of cortical neurons of their pups was tested. Stimulation of the sensorimotor cortex of rats prenatally exposed to hypoxia shortened the duration of cortical afterdischarges in 12-day-old rats, but did not change the excitability in 25-day-old animals. Shortening of the first afterdischarge in 35-day-old rats but the prolongation of the first afterdischarge in adult rats (as compared to the duration of cortical afterdischarges in rats not exposed to prenatal hypoxia) were registered. The possible mechanisms of different excitability of cortical neurons in rats prenatally exposed to hypobaric hypoxia are discussed.


Key words
Hypoxia · Development · Excitability of neurons · Rats

Reprint requests
D. Marešová, Institute of Physiology, First Faculty of Medicine, Charles University, Albertov 5, CZ-128 00 Prague 2, Czech Republic. E-mail:
dana.maresova@lf1.cuni.cz


PHYSIOLOGICAL RESEARCH
© 2001 by the Institute of Physiology, Czech Academy of Sciences

ISSN 0862 - 8408

Issue 2