Excitability
Changes of Cortical Neurons during the Postnatal
Period in Rats Exposed to Prenatal Hypobaric
Hypoxia
D.
MAREŠOVÁ, I. VALKOUNOVÁ, K. JANDOVÁ, J.
BORTELOVÁ, S. TROJAN
Institute
of Physiology, First Faculty of Medicine, Charles
University, Prague, Czech Republic
Received June 14, 2000
Accepted August 29, 2000
Summary
Pregnant rats were exposed to
intermittent hypobaric hypoxia (at a simulated
altitude of 7000 m or 5000 m) and the
excitability of cortical neurons of their pups
was tested. Stimulation of the sensorimotor
cortex of rats prenatally exposed to hypoxia
shortened the duration of cortical
afterdischarges in 12-day-old rats, but did not
change the excitability in 25-day-old animals.
Shortening of the first afterdischarge in
35-day-old rats but the prolongation of the first
afterdischarge in adult rats (as compared to the
duration of cortical afterdischarges in rats not
exposed to prenatal hypoxia) were registered. The
possible mechanisms of different excitability of
cortical neurons in rats prenatally exposed to
hypobaric hypoxia are discussed.
Key
words
Hypoxia · Development · Excitability
of neurons · Rats
Reprint requests
D. Marešová, Institute of Physiology,
First Faculty of Medicine, Charles University,
Albertov 5, CZ-128 00 Prague 2, Czech Republic.
E-mail: dana.maresova@lf1.cuni.cz
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