Impact
of Antihypertensive Therapy on the Skeleton:
Effects of Enalapril and AT1 Receptor Antagonist
Losartan in Female Rats
P.D.
BROULÍK1,V. TESAŘ2, T.
ZIMA3, M. JIRSA2
1Third
Medical Clinic, 2First
medical Clinic and 3Institute
of Clinical Chemistry, First Faculty of Medicine,
Charles University, Prague, Czech Republic
Received October 17,
2000
Accepted January 23, 2001
Summary
No
data are available about the effects of AT1
receptor antagonist losartan on the skeleton and
there is also little information on the activity
of an ACE inhibitor enalapril on bone metabolism.
It is widely believed that the vasculature plays
an important role in bone remodeling under normal
and pathological conditions. We treated
14-week-old female Wistar rats with losartan,
enalapril or saline. Administration of the ACE
inhibitor enalapril and angiotensin II antagonist
losartan had no effect on total malondialdehyde
(MDA) in the blood and on urinary excretion of
some eicosanoids and their metabolites. The
administration of enalapril and losartan in a
dose recommended for the treatment of
hypertension did not cause significant changes in
bone density, the ash and mineral content or
morphometric parameters of the femur compared to
the values found in control female rats.
Key
words
Enalapril
· Losartan · Female rats · Bone metabolism
Reprint
requests
P.
Broulík, Third Internal Clinic, First Faculty of
Medicine, Charles University, U nemocnice 1, 128
21 Prague, Czech Republic
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