Combination
of Drugs Elevating Extracellular Adenosine with
Granulocyte Colony-Stimulating Factor Promotes
Granulopoietic Recovery in the Murine Bone Marrow
after
5-Fluorouracil Treatment
M.
HOFER, M. POSPÍŠIL, L. WEITEROVÁ, V. ZNOJIL1,
J. VÁCHA1, J. HOLÁ, A. VACEK, I.
PIPALOVÁ
Institute
of Biophysics, Academy of Sciences of the Czech
Republic, and 1Faculty of Medicine, Masaryk
University, Brno, Czech Republic
Received November 21,
2000
Accepted March 16, 2001
Summary
Combined
administration of drugs elevating extracellular
adenosine, namely dipyridamole and adenosine
monophosphate, together with granulocyte
colony-stimulating factor was shown to enhance
granulopoietic recovery in the bone marrow of
mice treated with 5-fluorouracil. Enhanced
regeneration was found both at the level of
hematopoietic progenitor cells for granulocytes
and macrophages and in the compartment of
morphologically recognizable granulocyte
precursors. The results might have positive
clinical impact. The adjunct use of drugs
elevating extracellular adenosine might reduce
the cost expenditure of therapy with granulocyte
colony-stimulating factor.
.
Key
words
5-fluorouracil
· Granulopoiesis · Extracellular adenosine ·
Adenosine monophosphate · Dipyridamole ·
Granulocyte colony-stimulating factor
Reprint
requests
Dr.
Michal Hofer, Institute of Biophysics, Academy of
Sciences of the Czech Republic, Královopolská
135, CZ-612 65 Brno, Czech Republic, fax:
004205/41211293, e-mail: hofer@ibp.cz
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