Volume 50: 521-524, 2001

SHORT COMMUNICATION


Combination of Drugs Elevating Extracellular Adenosine with Granulocyte Colony-Stimulating Factor Promotes Granulopoietic Recovery in the Murine Bone Marrow after
5-Fluorouracil Treatment

M. HOFER, M. POSPÍŠIL, L. WEITEROVÁ, V. ZNOJIL1, J. VÁCHA1, J. HOLÁ, A. VACEK, I. PIPALOVÁ

Institute of Biophysics, Academy of Sciences of the Czech Republic, and 1Faculty of Medicine, Masaryk University, Brno, Czech Republic


Received November 21, 2000
Accepted March 16, 2001


Summary
Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes and macrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor.
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Key words
5-fluorouracil · Granulopoiesis · Extracellular adenosine · Adenosine monophosphate · Dipyridamole · Granulocyte colony-stimulating factor


Reprint requests
Dr. Michal Hofer, Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, CZ-612 65 Brno, Czech Republic, fax: 004205/41211293, e-mail: hofer@ibp.cz



PHYSIOLOGICAL RESEARCH
© 2001 by the Institute of Physiology, Czech Academy of Sciences

ISSN 0862 - 8408

Issue 5