Protective
Effect of Quercetin on
Ischemia/Reperfusion-induced Gastric Mucosal
Injury in Rats
J.
MOJŽIŠ, K. HVIŠČOVÁ, D. GERMANOVÁ, D.
BUKOVIČOVÁ,
L. MIROSSAY
Department
of Pharmacology, Medical Faculty, Šafárik
University, Košice, Slovak Republic
Received December 11,
2000
Accepted February 6, 2001
Summary
This
study was designed to determine the
gastroprotective properties of quercetin in
ischemia/reperfusion-induced gastric mucosal
injury and the involvement of endogenous
prostaglandins in this process. Oral pretreatment
of rats with quercetin (100 mg.kg-1) 30 min
before surgery significantly decreased the length
of gastric mucosal lesions. However, lower doses
of quercetin (25 and 50 mg.kg-1) only slightly
decreased the gastric mucosal injury.
Intraperitoneal application of indomethacin (5
mg.kg-1) had no effect in control (sham-operated)
animals, but significantly worsened gastric
injury in non-treated animals after
ischemia/reperfusion. Furthermore, indomethacin
only slightly reversed protective effect of
quercetin. Non-treated animals showed a marked
decrease in adherent mucus after
ischemia/reperfusion. On the other hand,
application of quercetin prevented this
significant decrease even in animals pretreated
with indomethacin. It can be concluded that
antioxidant properties of quercetin and its mucus
protective effect might be the main factors
responsible for its protective effect against
ischemia/reperfusion-induced gastric mucosal
injury.
Key
words
Quercetin
· Gastric mucosa · Ischemia/Reperfusion ·
Indomethacin · Rats
Reprint
requests
Assoc.
Prof. Ján Mojžiš, Ph.D., Department of
Pharmacology, Medical Faculty, P.J. Šafarik
University, Tr. SNP 1, 040 66 Košice, Slovak
Republic, fax: ++ 421 95428524, e-mail: mojzis@central.medic.upjs.sk
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