Effects of Pleuran
(ß-Glucan Isolated from Pleurotus ostreatus) on
Experimental Colitis in Rats
V. NOSÁĽOVÁ,
P. BOBEK1, S. ČERNÁ1, Š. GALBAVÝ2,
S. ŠTVRTINA2
Institute
of Experimental Pharmacology, Slovak Academy of
Sciences, 1Research
Institute of Nutrition and 2Institute of
Pathological Anatomy, School of Medicine,
Comenius University, Bratislava, Slovak Republic
Received
November 13, 2000
Accepted February 28, 2001
Summary
The
effects of pleuran, ß-1,3 glucan isolated from
Pleurotus ostreatus, were studied in a model of
acute colitis induced by intracolonic
administration of acetic acid. There was a
reduction of the colonic damage score, colonic
wet weight and wet/dry weight ratio 48 h after
single luminal 2 % pleuran suspension
pretreatment. Similar results were obtained after
repeated intraperitoneal administration of
pleuran in doses of 30 and 100 mg/kg. Pleuran
given orally as a 10 % food component over 4
weeks was effective in reducing the extent of
mucosal damage, but did not prevent the increase
of myeloperoxidase in the injured colonic
segment. In the segment without macroscopic
evidence of inflammation, myeloperoxidase
activity was significantly lower as documented by
histological examination. The results indicate a
possible role of this immunomodulator in the
treatment of ulcerative colitis.
Key words
Pleuran
· Glucan · Acetic acid induced
colitis · Rats
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Viera
Nosáľová, M.D., Ph.D., Institute of
Experimental Pharmacology, Slovak Academy of
Sciences, Dúbravská cesta 9, 842 16 Bratislava,
Slovak Republic. E-mail: exfanosv@savba.sk
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