| Concentrations of
Free Mg2+, pH and 31P MR Metabolite Ratios in
Calf Muscles of Healthy Controls and Patients
with Primary Juvenile Hypertension
M.
HÁJEK, D. PALYZOVÁ1, M. KOŘÍNEK, D. KURKOVÁ
MR Unit, Institute for Clinical and Experimental
Medicine and 1Department
of Pediatrics, Third Faculty of Medicine, Charles
University, Prague, Czech Republic
Received June 29, 2000
Accepted July 9, 2001
Summary
31P MR spectroscopy was used
to measure the signal intensity ratios of
high-energy metabolites for the calculation of
free cytosolic magnesium concentration [fMg2+]
and pH in the calf muscles of patients with
primary juvenile hypertension and of healthy
controls. Surface coil and spectroscopic imaging
techniques were used. In patients with
hypertension, the concentrations of [fMg2+] was
788±33 mmol/l and intracellular pH was
7.05±0.02; these values were not significantly
different from the results obtained in healthy
controls ([fMg2+], 776±21 mmol/l and pH,
7.06±0.01). Biochemical assays of magnesium in
the serum (S-Mg) and in urine (DU-Mg) confirmed
this finding. Significant differences in the
relative signal intensities of high-energy
phosphates between patients with primary juvenile
hypertension and healthy controls were observed:
a) signal intensity ratios of PCr/Pi, PCr/PbATP,
PDE/PbATP were increased, and b) Pi/PDe, Pi/PATP
were decreased. The results were the same
irrespective of whether the surface coil method
or 31P spectroscopic imaging were
employed.
Key
words
Concentration
Mg2+ · pH · Muscles · 31P MR spectroscopy ·
Juvenile hypertension
Reprint
requests
Dr. Milan Hájek, MR Unit, Institute for Clinical
and Experimental Medicine, Vídeňská 1958/9,
140 21 Prague 4, Czech Republic
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