Volume 51: 145-150, 2002

The Effects of Cardiopulmonary Bypass with Hollow Fiber Membrane Oxygenator on Blood Clotting Measured by Thromboelastography


Department of Anesthesiology and Critical Care Medicine, Charles University, Second Faculty of Medicine and Institute for Postgraduate Medical Education, Prague, Czech Republic

Received February 8, 2001
Accepted August 3, 2001

In cardiac surgical patients we investigated the effects of cardiopulmonary bypass (CPB) with a hollow fiber membrane oxygenator on blood clotting measured by thromboelastography (TEG). We found only a minimal change in the strength of blood clot described either by the TEG parameter MA (maximum amplitude) or by the shear modulus G calculated from MA. After CPB there was also a significant tendency towards hypercoagulation as defined by shortened parameters R, K and increased ?-angle. After comparison with published data obtained in cardiac surgical patients using a bubble oxygenator we conclude that currently used extracorporeal technology exerts a less negative influence on blood clotting than had been conceived previously.

Key words
Blood clot · Thromboelastography · Cardiopulmonary bypass · Bleeding · Oxygenator

Reprint requests
Dr. M. Horáček, Department of Anesthesiology and Critical Care Medicine, Motol University Hospital, V Úvalu 84, 150 06 Prague 5, Czech Republic.

© 2002 by the Institute of Physiology, Czech Academy of Sciences

ISSN 0862 - 8408

Issue 2