SHORT
COMMUNICATION
Citalopram
Inhibits L-type Calcium Channel Current in Rat
Cardiomyocytes in Culture
J.
HAMPLOVÁ-PEICHLOVÁ1, J. KRŮŠEK3,
I. PACLT1, J. SLAVÍČEK2,
V. LISÁ3, F. VYSKOČIL3,4
1Psychiatric Clinic,
2Department of
Physiology, First Medical Faculty, Charles
University, 3Institute
of Physiology, Academy of Sciences of the Czech
Republic, Prague, 4Department
of Animal Physiology and Developmental Biology,
Charles University, Prague, Czech Republic
Received September 6, 2001
Accepted January 10, 2002
Summary
Selective serotonine reuptake inhibitors
(SSRI) are believed to be less dangerous in the
treatment of depressive disorder in comparison
with tricyclic antidepressants (TCA) due to their
relative lack of cardiotoxicity. Thus, we
investigated the effect of citalopram (SSRI) on
membrane electrophysiology in rat cardiomyocytes
in tissue culture. The results were compared with
those from amitriptyline (TCA). The whole-cell
configuration patch-clamp technique was used.
Both citalopram and amitriptyline exhibited the
concentration-dependent inhibition of the L-type
calcium channel current (ICa). Citalopram in
concentrations of 3 mM and 10 mM inhibited peak
calcium current by 2.7 % and 8 %, respectively.
We demonstrated the same potency of citalopram
and amitriptyline to inhibit ICa. These
observations led us to conclude that citalopram
and amitriptyline are drugs, which exhibit a
similar potency for causing
concentration-dependent inhibition of ICa.
Key
words
Citalopram
· Amitriptyline · L-type calcium channel
current · Whole cell configuration patch-clamp
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J. Hamplová, Psychiatric Clinic, The First
Medical Faculty, Charles University, Ke Karlovu
11, CZ-128 00 Prague 2, Czech Republic
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