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MINIREVIEW
Fluoride Plus Aluminum: Useful Tools in
Laboratory Investigations, but Messengers of False Information
A. STRUNECKÁ1,
O. STRUNECKÝ2, J.
PATOČKA3
1Department of Physiology and Developmental Biology,
Faculty of Sciences, Charles University Prague, 2Department
of Hydrobiology, and 3Military Medical Academy,
Department of Toxicology, Hradec Králové, Czech Republic
Received
March 22, 2001
Accepted May 27, 2002
Summary
Aluminofluoride complexes (AlFx) form spontaneously in aqueous
solutions containing fluoride and traces of aluminum ions and
appear to act as phosphate analogs. These complexes have become
widely utilized in laboratory investigations of various guanine
nucleotide-binding proteins. Reflecting on many laboratory
studies, a new mechanism of fluoride and aluminum action on the
cellular level is being suggested. The long-term synergistic
effects of these ions in living environment and their hidden
danger for human health are not yet fully recognized.
Key
words
Aluminum · Fluoride · Aluminofluoride complexes · G-protein ·
Second messenger
Reprint
requests
Prof. RNDr. Anna Strunecká, DSc., Department of Physiology and
Developmental Biology, Faculty of Sciences, Charles University,
Viničná 7, 128 43 Prague 2, Czech Republic. E-mail:
strun@natur.cuni.cz
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