Insulin-Like Growth Factor Binding Protein-3 in
Patients with Liver Cirrhosis
K. ŠÍDLOVÁ, M. PECHOVÁ, K. KOTAŠKA, R. PRŮŠA
Department of Clinical Biochemistry and Pathobiochemistry,
Second Medical Faculty, Charles University and Faculty Hospital
Motol, Prague, Czech Republic
Received
August 18, 2001
Accepted March 22, 2002
Summary
Aim of the study was to evaluate serum levels of insulin-like
growth factor binding protein-3 in patients with liver cirrhosis
and to compare serum IGFBP-3 levels with other liver function
tests. Fifty-one patients with liver cirrhosis were selected for
our study. We measured IGFBP-3 (1.67±1.06 mg/l, mean ± SD),
albumin (32±8 g/l), prealbumin (0.22±0.14 g/l), AST (2.29±2.38
mkat/l), ALT (2.11±4.83 mkat/l) and cholinesterase (mean
78.6±45.2 mkat/l) in the serum. There was a significant positive
correlation of serum IGFBP-3 with serum albumin and serum
cholinesterase. The correlation coefficient was much lower
between serum IGFBP-3 and serum prealbumin. There was no
significant correlation between serum AST, ALT and IGFBP-3.
Serum IGFBP-3 proves to be a better marker for the hepatic
synthetic capacity than serum albumin or cholinesterase.
Key
words
Liver cirrhosis · GFBP-3 · Liver tests
Reprint
requests
K. Šídlová, M.D., Department of Clinical Biochemistry and
Pathobiochemistry, Second Faculty of Medicine, Charles
University and Faculty Hospital Motol, V úvalu 84, 150 06 Prague
5, Czech Republic. Fax: +420 2 24435320, E-mail:
katerina.sidlova@email.cz
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