Biliary Decompression Reduces the
Susceptibility to Ethanol-Induced Ulcer in Jaundiced Rats
A. CINGI1, R. AHISKALI2,
B.K.OKTAR3, M.A. GÜLPINAR3, C. YEGEN1,
B.Ç. YEGEN3
Marmara University, School of Medicine, 1Departments
of General Surgery, 2Pathology
and 3Physiology, Istanbul,
Turkey
Received November 19,
2001
Accepted March 18, 2002
Summary
We investigated the gastric response to an ulcerogenic irritant
and the change in gastric functions in an experimental rat model
of obstructive jaundice, with or without biliary drainage. After
biliary obstruction for 14 days, rats with ligated bile duct
(BDL) were randomly divided into three groups: BDL group without
biliary drainage, BDL followed by choledochoduodenostomy (CD) or
a choledochovesical fistula (CVF). The gastric functions were
evaluated 2 weeks after the surgery. Gastric damage, induced by
orogastric administration of ethanol, was evaluated 30 min later
using a lesion index and microscopic scoring was then performed
on fixed stomachs. Basal gastric acid secretion was measured by
the pyloric ligation method.The lesion index and maximum lesion
depth did not differ in the BDL and sham groups, while they were
significantly reduced in the CD group. Gastric acid output and
secretory volume were reduced in the BDL group compared to the
sham group, while these reductions were abolished in the CD
group. Afferent denervation with capsaicin further reduced the
ulcer index in the later group. Our data suggest that gastric
mucosal susceptibility to injury is dependent on the normal flow
of bile into the duodenal lumen, which appears to be a
requirement for adaptive gastric cytoprotection.
Key
words
Hypertension · Transgenic rat · Neuronal nitric oxide synthase ·
Renal nerves · Renal hemodynamics
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