Physiol. Res. 51: 629-632, 2002

 

Hematopoiesis-Stimulating and Anti-Tumor Effects of Repeated Administration of Diclofenac in Mice with Transplanted Fibrosarcoma Cells

M. HOFER, Z. HOFEROVÁ, P. FEDOROČKO1, N.O. MACKOVÁ1

Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic and 1Department of Cellular and Molecular Biology, Faculty of Sciences, P.J. Šafárik University, Košice, Slovak Republic

Received November 21, 2001
Accepted March 7, 2002


Summary
Positive effects of repeated administration of diclofenac, an inhibitor of prostaglandin synthesis, in terms of prevention of tumor development and stimulation of hematopoiesis have been observed in C3H mice transplanted subcutaneously with G:5:113 fibrosarcoma cells. Fourteen-day treatment with diclofenac (3.75 mg/kg/day) started from day 5 after tumor cell transplantation. Measurements of tumors and hematological examinations were performed on day 30. The results strongly suggest the possibility that inhibitors of prostaglandin synthesis (non-steroidal anti-inflammatory drugs) may be used in oncological practice where the observed effects are highly desirable.


Key words
Diclofenac · Prostaglandins · Hematopoiesis · Fibrosarcoma


Reprint requests
Dr. Michal Hofer, Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, CZ-612 65 Brno, Czech Republic, fax 004205/41517171, E-mail: hofer@ibp.cz


PHYSIOLOGICAL RESEARCH
© 2002 by the Institute of Physiology, Czech Academy of Sciences

ISSN 0862 - 8408

Issue 6