Hematopoiesis-Stimulating and Anti-Tumor
Effects of Repeated Administration of Diclofenac in Mice with
Transplanted Fibrosarcoma Cells
M. HOFER, Z. HOFEROVÁ, P. FEDOROČKO1,
N.O. MACKOVÁ1
Institute of Biophysics, Academy of Sciences of the Czech
Republic, Brno, Czech Republic and 1Department of
Cellular and Molecular Biology, Faculty of Sciences, P.J.
Šafárik University, Košice, Slovak Republic
Received November 21,
2001
Accepted March 7, 2002
Summary
Positive effects of repeated administration of diclofenac, an
inhibitor of prostaglandin synthesis, in terms of prevention of
tumor development and stimulation of hematopoiesis have been
observed in C3H mice transplanted subcutaneously with G:5:113
fibrosarcoma cells. Fourteen-day treatment with diclofenac (3.75
mg/kg/day) started from day 5 after tumor cell transplantation.
Measurements of tumors and hematological examinations were
performed on day 30. The results strongly suggest the
possibility that inhibitors of prostaglandin synthesis
(non-steroidal anti-inflammatory drugs) may be used in
oncological practice where the observed effects are highly
desirable.
Key
words
Diclofenac · Prostaglandins · Hematopoiesis · Fibrosarcoma
Reprint
requests
Dr. Michal Hofer, Institute of Biophysics, Academy of Sciences
of the Czech Republic, Královopolská 135, CZ-612 65 Brno, Czech
Republic, fax 004205/41517171, E-mail:
hofer@ibp.cz
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