Hepatotoxic Effect of D-Galactosamine and Protective Role of
Lipid Emulsion
R. FERENČÍKOVÁ, Z. ČERVINKOVÁ, Z. DRAHOTA1
Department of Physiology, Medical Faculty, Charles
University, Hradec Králové and 1Institute of Physiology,
Academy of Sciences of the Czech Republic, Prague, Czech
Republic
Received
February 6, 2002
Accepted May 27, 2002
Summary
D-galactosamine is a hepatotoxic agent, which induces diffuse
injury of liver tissue followed by the regeneration process. Our
data showed a high increase of serum aminotransferases after D-galactosamine
administration, which indicates a high extent of liver injury.
When lipid emulsion was applied immediately after D-galactosamine,
the increase of serum aminotransferases was greatly reduced. In
addition, the decrease of the cytochrome c oxidase activity
induced by D-galactosamine was not observed after lipid emulsion
administration and the increase of total liver oxidative
capacity in the regeneration period due to activated
mitochondrial biogenesis was accelerated. All these findings
indicate a protective effect of lipid emulsion administration
against D-galactosamine toxicity.
Key
words
D-galactosamine hepatotoxicity • Liver regeneration • Cytochrome
c oxidase • Lipid emulsion
Reprint
requests
Doc.MUDr. Zuzana Červinková, CSc., Department of Physiology,
Medical Faculty, Charles University in Hradec Králové, Šimkova
870, 500 01 Hradec Králové, Czech Republic, e-mail:
wolff@lfhk.cuni.cz
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