IgA and IgG Antigliadin, IgA Anti-tissue
Transglutaminase and Antiendomysial Antibodies in Patients with
Autoimmune Thyroid Diseases and Their Relationship to Thyroidal
Replacement Therapy
J. JISKRA, Z. LÍMANOVÁ, Z. VANÍČKOVÁ1, P. KOCNA1
Third Medical Department and 1Department of
Clinical Biochemistry, First Medical Faculty, Charles
University, Prague, Czech Republic
Received June 5, 2002
Accepted June 23, 2002
Summary
Celiac disease is a chronic illness of the small bowel caused by
gliadin intolerance in genetically predisposed subjects. The aim
of this study was to investigate serum levels of IgA and IgG
antigliadin antibodies, IgA antiendomysial antibodies, and IgA
anti-tissue transglutaminase antibodies in 169 patients with
autoimmune thyroid diseases, i.e. chronic thyroiditis and
Graves´ disease. Antiendomysial antibodies were positive in 2
out of 169 persons (1.18 %), IgA antigliadin antibodies in 15.98
%, IgG antigliadin antibodies in 51.48 %, and IgA anti-tissue
transglutaminase in 14.79 %. The prevalence of positivity was
higher compared to the 1312 control blood donors described in
our previous study (Vančíková et al. 2002) (p<0.05). Patients
with chronic thyroiditis treated with a high replacement dosage
of levothyroxin (125-200 μg daily) had higher serum levels of
IgA antigliadin antibodies in comparison with patients treated
with a lower dosage (50-100 μg daily) (medians: 13.00 vs. 19.69,
p=0.033). We found a negative correlation of IgA anti-tissue
transglutaminase antibodies and total calcium serum levels (r =
–0.480, p=0.0236, n=22). We can conclude that in persons with
autoimmune thyropathy there is a high prevalence of positive
antigliadin, anti-tissue transglutaminase and antiendomysial
antibodies. Latent celiac disease may lead to impaired
resorption of therapeutically administered levothyroxine,
calcium, or other substances.
Key
words
Celiac disease • Antigliadin antibodies • Thyroid
autoimmunity
Reprint
requests
MUDr. Jan Jiskra, Third Internal Clinic, First Medical Faculty
Charles University, U nemocnice 1, 128 08 Prague 2, Czech
Republic,
jan.jiskra@seznam.cz
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