Physiol. Res. 52: 265-267, 2003


Comparison of Cytokine Levels in Sera of Patients with Autoimmune Endocrinopathies


1Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University and 2Institute of Endocrinology, Prague, Czech Republic

Received April 3, 2002
Accepted June 14, 2002

Autoimmune endocrinopathies can be divided according to the presence of organ specific autoantibodies and according to the clinical manifestations into isolated autoimmune endocrinopathies, autoimmune polyglandular syndromes (APS) and polyglandular activation of autoimmunity (PAA). Many factors take part in the development of the autoimmune disease: predominantly a genetic predisposition, environmental etiologic causes and dysregulation in the microenvironment of the target organ. Until now it is not completely clear, if manifestations of the clinical disease depend primarily upon external factors and the degree of regulation mechanism disorder (e.g. in Th1/Th2 regulation) or upon the different genetic predisposition. In this work we compared the levels of Th1 and Th2 lymphocyte cytokines in peripheral blood in three groups of patients: group A of 30 patients with autoimmune thyroiditis, group B of 25 patients with PAA, and group C of 10 patients with APS type II. From group of Th1 cytokines IL-2 and IFN- were detected, whereas from group of Th2 cytokines IL-4 and IL-10 were determined by ELISA kit. We did not find any differences in the concentrations of IL-2, IFN-, IL-4 and IL-10 among the groups of patients with autoimmune endocrinopathies.

Key words
Autoimmune thyroiditis • APS type II • Polyglandular activation of autoimmunity • Cytokines

Reprint requests
MUDr. P. Hrdá, Institute of Endocrinology, Národní 8, 116 94 Prague 1, Czech Republic. E-mail

© 2003 by the Institute of Physiology, Czech Academy of Sciences