SHORT COMMUNICATION
Comparison of Cytokine Levels in Sera of Patients with
Autoimmune Endocrinopathies
P. HRDÁ1,2, I. ŠTERZL1,2,
P. MATUCHA2
1Institute of Immunology and Microbiology,
First Faculty of Medicine, Charles University and 2Institute
of Endocrinology, Prague, Czech Republic
Received
April 3, 2002
Accepted June 14, 2002
Summary
Autoimmune endocrinopathies can be divided according to the
presence of organ specific autoantibodies and according to the
clinical manifestations into isolated autoimmune
endocrinopathies, autoimmune polyglandular syndromes (APS) and
polyglandular activation of autoimmunity (PAA). Many factors
take part in the development of the autoimmune disease:
predominantly a genetic predisposition, environmental etiologic
causes and dysregulation in the microenvironment of the target
organ. Until now it is not completely clear, if manifestations
of the clinical disease depend primarily upon external factors
and the degree of regulation mechanism disorder (e.g. in Th1/Th2
regulation) or upon the different genetic predisposition. In
this work we compared the levels of Th1 and Th2 lymphocyte
cytokines in peripheral blood in three groups of patients: group
A of 30 patients with autoimmune thyroiditis, group B of 25
patients with PAA, and group C of 10 patients with APS type II.
From group of Th1 cytokines IL-2 and IFN- were detected,
whereas from group of Th2 cytokines IL-4 and IL-10 were
determined by ELISA kit. We did not find any differences in the
concentrations of IL-2, IFN-, IL-4 and IL-10 among the groups
of patients with autoimmune endocrinopathies.
Key
words
Autoimmune thyroiditis • APS type II • Polyglandular
activation of autoimmunity • Cytokines
Reprint
requests
MUDr. P. Hrdá, Institute of Endocrinology, Národní 8, 116 94
Prague 1, Czech Republic. E-mail
phrda@endo.cz
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