Physiol. Res. 52: 347-351, 2003

Soluble Leptin Receptor Levels in Patients with Chronic Renal Failure


1Third Department of Medicine and 2Department of Internal Medicine Strahov, First Medical Faculty, Charles University, Prague, Czech Republic

Received  March 25, 2002
Accepted June 25, 2002

Soluble leptin receptor (SLR) is the extracellular part of the leptin receptor. This protein is released into circulation and constitutes the main circulating leptin-binding protein. The aim of our study was to measure SLR concentrations in patients with chronic renal failure (CRF) and healthy subjects and to explore the relationship of SLR to other hormones and cytokines. The patients with CRF had significantly higher serum leptin, TNF-a and insulin levels than healthy subjects (25.1±23.5 vs. 9.4±7.6 (S.D.); 14.2±4.2 vs. 4.55±2.5; 39.8±36.1 vs. 20.3±11.1 mU.l-1). Serum soluble leptin receptor levels did not differ between these groups (19.1±11.3 vs. 19.6±6.1 An inverse relationship between serum SLR and leptin levels was found in both groups. In patients with CRF the inverse relationship between SLR and insulin, body fat content and total protein levels were also found, while in healthy subjects only inverse relationship of SLR with insulin and albumin concentrations were detected. We conclude that soluble leptin receptor levels in patients with chronic renal failure do not differ from those of healthy subjects despite higher serum leptin levels in CRF patients. The physiological consequences of this finding require further investigation.

Key words
Soluble leptin receptor • Leptin • Anorexia • Chronic renal failure

Reprint requests
Jarmila Křížová, MD, Third Medical Department, First Faculty of Medicine, Charles University, U nemocnice 1, 120 00 Prague 2, Czech Republic, e-mail:

© 2003 by the Institute of Physiology, Czech Academy of Sciences