Molecular Pathways of Endoplasmic Reticulum Dysfunctions:
Possible Cause of Cell Death in the Nervous System
J. LEHOTSKÝ, P. KAPLÁN, E.
BABUŠÍKOVÁ, A. STRAPKOVÁ, R. MURÍN
Comenius University, Jessenius Faculty of Medicine,
Martin, Slovak Republic
Received April 29, 2002
Accepted July 4, 2002
This review summarizes recent information on the role of calcium
in the process of neuronal injury with special attention to the
role of calcium stores in the endoplasmic reticulum (ER).
Experimental results present evidence that ER is the site of
complex processes such as calcium storage, synthesis and folding
of proteins and cell response to stress. ER function is impaired
in many acute and chronic diseases of the brain which in turn
induce calcium store depletion and conserved stress responses.
Understanding the mechanisms leading to ER dysfunction may lead
to recognition of neuronal protection strategies.
Endoplasmic reticulum • Calcium store • Neuron • Damage
Prof. Ján Lehotský, PhD., Comenius University, Jessenius Faculty
of Medicine, Department of Medical Biochemistry, Malá Hora 4,
03601 Martin, Slovak Republic, e-mail: