Electrocardiographic Dose-Dependent Changes in Prophylactic
Doses of Dosulepine, Lithium and Citalopram
I. PACLT1, J.
SLAVÍČEK2, A. DOHNALOVÁ2, E.
KITZLEROVÁ1, K. PIŠVEJCOVÁ1
1Department of Psychiatry, and 2Institute
of Physiology, First Faculty of Medicine, Charles
University, Prague, Czech Republic
Received July 23, 2002
Accepted October, 9, 2002
Summary
Tricyclic
antidepressant drugs dosulepine (TCA), serotonin selective
reuptake inhibitor (SSRI) and prophylactic agent with
antidepressant effect lithium carbonicum (Li) have different
cardiovascular side-effects. We compared them in the
prophylactic therapy of periodic affective disorder in remission
with TCA, SSRI and Li. Our previous papers confirmed the most
prominent effects of heart electric field parameters in TCA
patients (Slavíček et al. 1998). In the present work we
studied for the first time the dose-dependent changes of ECG,
body surface potential maps (BSPM – parameter DIAM 30, 40) in 43
TCA dosulepine, 40 SSRI citalopram and 30 Li outpatients (Hamilton
scale: HAMD£10;
age 40±5
years; treated for depressive disorders or bipolar disorders).
The daily doses of dosulepine were 50-250 mg, citalopram 20-80
mg, Li plasma levels 0.66±0.08
meq/l. The electrocardiogram (ECG), vectorcardiogram (VCG), and
BSPM were measured and calculated by the Cardiag 112.1
diagnostic system. The results have shown a relation between the
dose of dosulepine and extremum (maximum and minimum) of
depolarization isoarea map in dosulepine, but not in citalopram
patients. The repolarization BSPM changes were most pronounced
in SSRI patients. Lithium in long-term prophylaxy (1-22 years)
caused only minimal ECG BSPM changes. The present results
correspond with our previous observations.
Key
words
ECG • Body surface potential maps • Dosulepine •
Citalopram • Dose-dependent changes • Lithium • Prophylactic
doses
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MUDr. Ivo Paclt, CSc, Department of Psychiatry, First Faculty of
Medicine, Charles University, Ke Karlovu 11, 128 02 Prague 2,
Czech Republic, e-mail:
pacltovi@email.cz
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