Office Blood Pressure, Heart Rate and A(-596)G Interleukin-6
Gene Polymorphism in Apparently Healthy Czech Middle-Aged
Population
A. VAŠKŮ, M. SOUČEK1,
M. GOLDBERGOVÁ, J. VÁCHA
Institute of Pathological Physiology, Faculty of Medicine,
Masaryk University and 1First Clinic of
Internal Medicine, St. Ann´s Faculty Hospital, Masaryk
University, Brno, Czech Republic
Received
February 2, 2002
Accepted June 24, 2002
Summary
The aim of the study was to assess the association between
promoter polymorphism [A(-596)G] in interleukin-6 gene and
office systolic and diastolic blood pressures, and the heart
rate (HR) in apparently healthy Czech subjects. Furthermore, we
evaluated the possible influence of gender, BMI and smoking on
these supposed associations. An age-matched (40-50 years) and
gender-matched (F/M=81/89) sample of apparently healthy Czech
subjects (n=170, F/M=81/89) without hypertension, other
cardiovascular diseases or diabetes was examined. The A(-596)G
Il-6 gene polymorphism was detected by the PCR method. No
differences in genotype distribution and/or allelic frequency
was found between groups with lower systolic blood pressure (£ 122
mm Hg) and higher systolic blood pressure (> 122
mm Hg). Similarly, no differences in the IL-6 polymorphism were
found between lower (£ 86
mm Hg) and higher (> 86
mm Hg) diastolic blood pressure groups. However, we proved a
significant increase of genotypes AG+GG as well as the allele
(‑596)G in higher (>78
beats/min) heart rate group. The genotypes AG+GG represent
significantly higher relative risk for higher HR frequency,
especially in women. Among lean persons with a low heart rate
frequency, fewer AG+GG genotypes were determined than among any
other subjects. The genotypes AG+GG are more frequent in
non-smoking persons with higher HR compared to non-smoking
subjects with lower HR, especially in women. Gender, BMI and
smoking substantially modify the distribution of A(-596)G
Il-6 gene polymorphism in apparently healthy persons with
lower or higher heart rate.
Key
words
Blood pressure • Heart rate • Interleukin 6 • Gene
polymorphism • Healthy subjects • BMI • Smoking
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requests
Anna Vašků, M.D., PhD., Institute of Pathological Physiology,
Faculty of Medicine, Masaryk University, Komenského nám. 2, 662
43 Brno, Czech Republic, e-mail:
avasku@med.muni.cz
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