Role of Endothelin and Nitric Oxide in the Pathogenesis of
Arterial Hypertension in Autosomal Dominant Polycystic Kidney
Disease
M. MERTA, J. REITEROVÁ, R.
RYŠAVÁ, V. TESAŘ, J. ZÁVADA, M. JÁCHYMOVÁ1, T. ZIMA1
First Internal Clinic and 1Institute of
Clinical Biochemistry, First Faculty of Medicine, Charles
University, Prague, Czech Republic
Received May 2, 2002
Accepted August 19, 2002
Summary
The pathogenesis of arterial hypertension in autosomal dominant
polycystic kidney disease (ADPKD) is complex and likely
dependent on interaction of hemodynamic, endocrine and
neurogenic factors. We decided to evaluate the role of
endothelin (ET1) and nitric oxide (NO) in the regulation of
arterial blood pressure (BP) and to determine plasma levels of
ET1 and NO in the group of patients with ADPKD. The ADPKD group
(18 patients, 6 men + 12 women, mean age 44.611.7 years, with
creatinine clearancecorrig > 1.1 ml/s) was compared with a
control group of 27 healthy volunteers of comparable age. Plasma
levels of ET1 assessed by direct RIA determination in the group
of ADPKD patients (11.031.8 fmol/ml) were significantly
increased (p<0.001) in comparison with the control group
(2.660.58 fmol/ml), while no significant differences were
observed between normotensive and hypertensive patients in the
ADPKD group. Serum levels of NO were evaluated according to the
determination of serum levels of their metabolites –
nitrites/nitrates. Serum levels of NO in the group of ADPKD
patients (39.85±6.38 μmol/l) were significantly higher (p<0.05)
in comparison with the control group (22.7±1.20 μmol/l), whereas
in the ADPKD group no significant differences were observed
between normotensive and hypertensive patients. Thus, our study
supports the concept of complex alteration of both
vasoconstrictor and vasodilator systems in the pathogenesis of
arterial hypertension in ADPKD.
Key
words
Endothelin • Nitric oxide • Autosomal dominant polycystic
kidney disease • Arterial hypertension • Chronic renal failure
Reprint
requests
Doc. MUDr Miroslav Merta, PhD., First Internal Clinic, First
Faculty of Medicine, Charles University, U nemocnice 2, 128 08
Prague 2, Czech Republic. E-mail:
Merta@mbox.cesnet.cz
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