RAPID COMMUNICATION
Action of GABA-B Antagonist on
Cortical Epileptic Afterdischarges in Rats is Similar to that of
GABA-A Antagonist
D. ŽIVANOVIĆ1,2, K. BERNÁŠKOVÁ1,3,
YU. KAMINSKIJ1, P. MAREŠ1
1Institute of Physiology, Academy of Sciences of the
Czech Republic, Prague, Czech Republic
2Institute of Physiology, Medical School, Belgrade,
Yugoslavia, 3Charles University, Third Faculty of
Medicine, Department of Normal, Pathological, and Clinical
Physiology, Prague, Czech Republic
Received July 2, 2003
Accepted July 25, 2003
Summary
Threshold intensities for epileptic phenomena induced by
cortical stimulation were used for comparison of the action of
GABA-B and GABA-A antagonists in rats with implanted electrodes.
Both CGP 35348 (200 mg/kg i.p.) and bicuculline (4 mg/kg i.p.)
significantly decreased thresholds for spike-and-wave
afterdischarges and their motor counterpart (clonic seizures)
whilst transition into the second, limbic type of afterdischarge
as well as threshold for movements directly bound to stimulation
remained uninfluenced by either drug.
Key words
Epileptic seizures • Cerebral cortex • Rat • CGP 35348 •
Bicuculline
Reprint requests
Prof. P. Mareš, M.D., D.Sc., Institute of Physiology, Academy of
Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague 4,
Czech Republic, e-mail:
maresp@biomed.cas.cz
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