Physiol. Res. 52: 805-808, 2003


Kynurenic Acid Prevented Social Recognition Deficits Induced by MK-801 in Rats


Institute of Physiology, Academy of Sciences of the Czech Republic and 1Department of Pharmacology, First Medical Faculty, Charles University, Prague, Czech Republic

Received January 14, 2003
Accepted March 13, 2003

MK-801 impaired social recognition potency of adult male rats when given immediately after the initial interaction with a juvenile rat. Administration of kynurenic acid prior to the initial interaction protected the adults against recognition deficits induced by MK-801. When re-exposed at a delay of 30 min to the familiar juvenile, social investigation in the adults was significantly reduced. Thus, the adults are able to remember olfactory stimuli emitted by juvenile con-specifics.

Key words
Amnesia Kynurenic acid MK-801 Social recognition Working memory

2003 by the Institute of Physiology, Czech Academy of Sciences