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SHORT COMMUNICATION
N-Methyl-D-Aspartate Prevented
Memory Deficits Induced by MK-801 in Mice
Z. HLIÒÁK, I. KREJÈÍ1
Institute of Physiology, Academy of Sciences of
the Czech Republic and 1Department of Pharmacology, First
Medical Faculty, Charles University, Prague, Czech Republic
Received January 14, 2003
Accepted March 13, 2003
Summary
An interaction between N-methyl-D-aspartate (NMDA) and MK-801 was examined in
mice using a modified elevated plus-maze paradigm that allows assessment of the
adaptive form of spatial memory. NMDA administered (s.c.) immediately after the
acquisition session protected the animals against the amnesia induced by MK-801
given shortly before the retention session. Behavioral performance, expressed as
the transfer latency, and therefore spatial memory potency of NMDA plus MK-801
treated animals was comparable with that of both NMDA-treated animals and the
controls.
Key words
N-methyl-D-aspartate • MK-801 • Spatial memory • Elevated
plus-maze • Mice
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