Physiol. Res. 52: 809-812, 2003


N-Methyl-D-Aspartate Prevented Memory Deficits Induced by MK-801 in Mice


Institute of Physiology, Academy of Sciences of the Czech Republic and 1Department of Pharmacology, First Medical Faculty, Charles University, Prague, Czech Republic

Received January 14, 2003
Accepted March 13, 2003

An interaction between N-methyl-D-aspartate (NMDA) and MK-801 was examined in mice using a modified elevated plus-maze paradigm that allows assessment of the adaptive form of spatial memory. NMDA administered (s.c.) immediately after the acquisition session protected the animals against the amnesia induced by MK-801 given shortly before the retention session. Behavioral performance, expressed as the transfer latency, and therefore spatial memory potency of NMDA plus MK-801 treated animals was comparable with that of both NMDA-treated animals and the controls.

Key words
N-methyl-D-aspartate MK-801 Spatial memory Elevated plus-maze Mice

2003 by the Institute of Physiology, Czech Academy of Sciences