Physiol. Res. 53: 83-89, 2004

Serum Levels of IGF-I, HGF, TGFβ1, bFGF and VEGF in Thyroid Gland Tumors


1Department of Otorhinolaryngology, Head and Neck Surgery, the First Medical Faculty of the Charles University, University Hospital Motol, 2ENT Department, Postgraduate School of Medicine, 3Institute of Endocrinology, 4Institute of Immunology and Microbiology, First Medical Faculty of Charles University, General University Hospital, Prague, Czech Republic

Received April 4, 2002
Accepted January 10, 2003

IGF-I, HGF, TGFβ1, bFGF and VEGF are involved in the pathogenesis of thyroid gland tumors and their growth. We decided to find whether changes in the production of these cytokines by thyroid tumor cells are reflected by changes of their peripheral blood. Using ELISA kits, we measured the concentrations of growth factors in the peripheral blood serum in 28 patients with thyroid gland tumors (14 adenomas, 14 papillary carcinomas) and compared these concentrations with those in healthy people. We found significantly lower serum levels of IGF-I in patients with thyroid adenoma compared to the healthy population. Serum levels of HGF and bFGF were significantly higher in patients with thyroid adenoma and papillary carcinoma compared with those in healthy subjects. Serum concentrations of TGFβ1 and VEGF were not significantly different in any groups of investigated subjects. Changes in the production of these cytokines by thyroid gland tumor cells are reflected in their peripheral blood levels, but these levels also depend on a number of other physiological and pathological processes in the organism. However, significant differences of HGF and bFGF serum levels can be explained by their very high production by thyroid tumor cells and by their strong effect on the follicular and endothelial cell proliferation.

Key words
Growth factors • Thyroid gland • Thyroid adenoma • Thyroid papillary carcinoma • Angiogenesis

© 2004 by the Institute of Physiology, Czech Academy of Sciences