Hyperlipoproteinemia
Impairs Endothelium-Dependent Vasodilation
P. KRAML1, P. SYROVÁTKA1, S. ŠTÍPEK2,
L. FIALOVÁ2, H. KOPŘIVOVÁ3, J. POTOČKOVÁ1,
M. ANDĚL1
1Second Department of Internal Medicine, Third
Faculty of Medicine, Charles University,
2First Department of Medical Chemistry, First Faculty
of Medicine, Charles University,
3Department of Medical Chemistry and Biochemistry,
Third Faculty of Medicine, Charles University, Prague, Czech
Republic
Received September 21, 2003
Accepted December 12, 2003
Summary
Atherogenic lipoproteins can cause endothelial dysfunction in
the initial stage of atherogenesis. In our study we examined 134
patients with defined hyperlipoproteinemia (non-HDL cholesterol
> 4.1 mmol/l or triglycerides > 2.5 mmol/l or taking any of
lipid lowering drugs) – 94 men and 40 women. The subgroup of
controls of comparable age contained 54 normolipidemic
individuals – 30 men and 24 women. Patients with
hyperlipoproteinemia revealed significantly lower ability of
endothelium-dependent flow-mediated vasodilation (EDV) measured
on brachial artery (4.13±3.07 vs. 5.41±3.82 %; p=0.032) and
higher carotid intima media thickness than normolipidemic
controls (0.68±0.22 vs. 0.58±0.15 mm; p=0.005). In regression
analysis, EDV correlated significantly with plasma
concentrations of oxLDL (p<0.05) HDL-cholesterol (p<0.05), Apo
A1 (p<0.05), ATI (p<0.01) and non-HDL cholesterol (p<0.05).
Patients with hyperlipoproteinemia showed higher plasma levels
of oxLDL (65.77±9.54 vs. 56.49±7.80 U/l; p=0.015),
malondialdehyde (0.89±0.09 vs. 0.73±0.08 µmol/l; p=0.010) and
nitrites/nitrates (20.42±4.88 vs. 16.37±4.44 µmol/l; p=0.018)
indicating possible higher long-term oxidative stress in these
patients.
Key words
Endothelium-dependent vasodilation • Hyperlipoproteinemia •
Oxidative stress • Oxidized LDL • Atherosclerosis
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