Caffeic Acid Phenethyl
Ester Improves Oxidative Organ Damage in Rat Model of Thermal
Trauma
A. GUREL1, F. ARMUTCU1, M. HOSNUTER2,
M. UNALACAK3,
E. KARGI2, C. ALTINYAZAR4
Zonguldak Karaelmas University Faculty of Medicine, 1Department
of Biochemistry and Clinical Biochemistry, 2Department
of Plastic and Reconstructive Surgery, 3Department of
Family Medicine and 4Department of Dermatology,
Zonguldak, Turkey
Received August 15, 2003
Accepted January 12, 2004
Summary
Severe burn injuries cause functional impairment in distant
internal organs. Although this mechanism is not clear, it is
possible that free radical toxicity plays an important role.
Research in animals and clinical studies have shown that there
is a close relationship between a lipid peroxidative reaction
and secondary pathological changes following thermal injury. It
has been demonstrated that antioxidant treatment prevents
oxidative tissue damage associated with thermal trauma. This
study was designed to determine the possible protective effect
of caffeic acid phenethyl ester (CAPE) treatment against
oxidative damage in the kidney and lung induced by thermal
injury. Rats were decapitated either 1, 3 or 7 days after burn
injury. CAPE was administered intraperitoneally immediately
after thermal injury. Kidney and lung tissues were taken for the
determination of malondialdehyde (MDA) level, myeloperoxidase
(MPO), catalase (CAT), superoxide dismutase (SOD) and xanthine
oxidase (XO) activities. Severe skin thermal injury caused a
significant decrease in SOD and CAT activities, as well as
significant increases in MDA level, XO and MPO activities in
tissues during the postburn period. Treatment of rats with CAPE
(10 mol/kg) significantly elevated the decreased SOD and CAT
activities, while it decreased MDA levels and MPO as well as XO
activity.
Key words
Burn • Oxidative damage • Lung • Kidney • CAPE • Honeybee
extracts
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