Physiol. Res. 53: 569-579, 2004

MINIREVIEW


Allostery and Cooperativity in the Interaction of Drugs
with Ionic Channel Receptors


J. KRيEK

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Received December 19, 2003
Accepted February 26, 2004



Summary
Allostery is an essential property of many physiological mechanisms. Cooperativity together with allostery is observed in the behavior of multisubunit receptors. Here we summarize and compare several approaches to the description and analysis of allosteric phenomena with emphasis on the receptors connected to ionic channels as a model. Several simplified methods are discussed in comparison with the microscopic kinetic scheme, affinity-efficacy separation and a thermodynamic approach.


Key words
Allostery • Cooperativity • Hill coefficient • Affinity • Efficacy • Nicotinic acetylcholine receptor


© 2004 by the Institute of Physiology, Czech Academy of Sciences