Hemodynamic Parameters in a
Surgical Devascularization Model of Fulminant Hepatic Failure in
the Minipig
E. KIESLICHOVÁ, M. RYSKA1, T.
PANTOFLÍČEK1, O. RYSKA1, R. ZAZULA,
J. SKIBOVÁ
Department of Anesthesiology, Resuscitation and Intensive Care
and 1Transplant Surgery Department, Institute for Clinical and
Experimental Medicine, Prague, Czech Republic
Received March 2, 2004
Accepted November 10, 2004
On-line available January 10, 2005
Summary
Animal models of fulminant hepatic failure (FHF) are important
for studying the pathophysiology of this process and for
evaluation of the efficacy of artificial and bioartificial liver
support systems. In experiments, hemodynamic parameters were
monitored in a group of minipigs with FHF induced by surgical
devascularization, and compared with those in a control group.
During the experiment, animals were analgosedated and were on
mechanical lung ventilation. Crystalloid and colloidal solutions
were administered and norepinephrine in continuous infusion was
applied if mean arterial pressure (MAP) decreased below 60 mm Hg
despite adequate intravascular volumes. An increase in heart
rate, and decreases in MAP and systemic vascular resistance,
compared with the baseline, occurred in the FHF group from 6 h
after surgery. A comparison of FHF and control groups revealed
no significant differences in systemic vascular resistance and
MAP until after 12 h after surgery (systemic vascular resistance
index: 953 FHF vs. 1658 controls; p0.05; MAP: 58.1 FHF vs. 76
controls; p0.05). No significant differences in CI were seen
between the FHF group and controls. FHF animals survived for
about 13 h after surgery, i.e. a period, which we consider long
enough to test a support device. The parameters are believed to
be quite adequate, as we were able to maintain satisfactory
hemodynamic stability in all experimental animals with induced
acute hepatic failure.
Key words
Fulminant/acute hepatic failure • Devascularization surgical pig
model • Hemodynamic parameters
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