Physiol. Res. 54: 623-629, 2005

Antioxidant Vitamin Levels Do Not Exhibit Negative Correlation with the Extent of Acute Myocardial Infarction


1Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, 2Department of Cardiology, Hospital of Pardubice, 3Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, 4Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Prague and 5Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic

Received August 29, 2004
Accepted December 15, 2004
On-line available February 16, 2005

Serum levels of vitamin E (VE), β-carotene (BC) and vitamin C (VC) were determined in 50 patients with the first acute myocardial infarction (AMI) before starting thrombolytical treatment. VE and BC were determined by HPLC, VC spectrophotometrically. The reperfused patients were divided according to vitamin concentrations into four groups. The lowest quartile was compared with the rest of the studied population (VE: group with high (H) > 15.6 μM > group with low (L), BC: H > 0.07 μM > L, VC: H > 25 μM > L) in the following parameters: extent of myocardial damage (area under the curves of troponin I, CK-MB during 48 h), arrhythmia and congestive heart failure occurrence, size of ejection fraction, positivity of ventricular late potentials. No significant differences between groups H and L for either VE, BC or VC were found (P±0.05). As no correlation between serum concentrations of vitamins E, C and β-carotene and the extent and clinical course of AMI was found, the actual vitamin concentrations may be important for prevention of ischemic heart a disease, but they do not play a decisive role in the acute phase of myocardial infarction in humans.

Key words
Antioxidant vitamins • α-Tocopherol • β-Carotene • Ascorbic acid • Myocardial infarction.

© 2005 by the Institute of Physiology, Czech Academy of Sciences