RAPID COMMUNICATION
Apoptosis as an Early Event in the Development
of Multiple Organ Failure?
J. PACHL, F. DUŠKA, P. WALDAUF, M. FRIC, J.
FANTA1, E. ŽĎÁRSKÝ2
Department of Anesthesiology and 1Surgery, 2Institute of
Pharmacology, Third Faculty of Medicine, Charles University,
Prague, Czech Republic
Received May 10, 2005
Accepted May 27, 2005
On-line available April 26, 2005
Summary
We have recently developed a simple method of plasma free DNA
detection, which enables us to distinguish between apoptotic and
genomic (necrotic) DNA. After applying this method to the
critically ill, we revealed apoptotic DNA on the day of
admission to be higher than later when multiple-organ failure
developed. Moreover, apoptotic DNA contributed to total plasma
DNA much more than DNA from necrotic cells and its increase
predicted future development of multiple-organ failure and
death.
Key words
Multiple-organ failure • Early apoptosis • Apoptic DNA • Plasma
free DNA
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