Physiol. Res. 54: 639-644, 2005

Biological Half-life of Bromide in the Rat Depends Primarily
on the Magnitude of Sodium Intake


1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, 2Department of Biochemistry, Faculty of Science, Masaryk University, Brno and 3Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Received August 23, 2004
Accepted January 21, 2005
On-line available February 16, 2005

The parallel course of the excretion rates of bromide and sodium ions was demonstrated in adult male and female rats administered simultaneously with potassium 82Br-bromide and 24Na-sodium chloride. The animals were exposed to various intakes of sodium ions accompanied with five different anions: Br-, Cl-, HCO3-, ClO4-, and SCN-. Regardless of the anion accompanying the sodium ion, the excretion rates of 82Br- and 24Na+ ions were proportional to the magnitude of sodium intake in the animals. Hence, we have proved our hypothesis that the biological half-life of bromide depends on the magnitude of sodium intake rather than on the intake of chloride.

Key words
Biological half-life • Bromide • Chloride • Sodium • Rat

© 2005 by the Institute of Physiology, Czech Academy of Sciences