Normocapnic High-frequency
Oscillatory Ventilation Affects Differently Extrapulmonary and
Pulmonary Forms of Acute Respiratory Distress Syndrome in Adults
J. PACHL, K. ROUBÍK1, P. WALDAUF, M. FRIC, V.
ZÁBRODSKÝ
University Department of Anesthesiology and Critical Care
Medicine, Third Faculty of Medicine, Charles University, and
1Faculty of Biomedical Engineering, Czech Technical
University, Prague, Czech Republic
Received February 28, 2005
Accepted March 4, 2005
On-line available April 26, 2005
Summary
The recently reported differences between pulmonary and
extrapulmonary acute respiratory distress syndromes (ARDSp,
ARDSexp) are the main reasons of scientific discussion on
potential differences in the effects of current ventilatory
strategies. The aim of this study is to assess whether the
presence of ARDSp or ARDSexp can differently affect the
beneficial effects of high-frequency oscillatory ventilation
(HFOV) upon physiological and clinical parameters. Thirty adults
fulfilling the ARDS criteria were indicated for HFOV in case of
failure of conventional ventilation strategy. According to the
ARDS type, each patient was included either in the group of
patients with ARDSp or ARDSexp. Six hours after normocapnic HFOV
introduction, there was no significant increase in PaO2/FIO2 in
ARDSp group (from 12947 to 13350 Torr), but a significant
improvement was found in ARDSexp (from 11454 to 20065 Torr,
p<0.01). Despite the insignificant difference in the latest mean
airway pressure (MAP) on conventional mechanical ventilation
(CMV) between both groups, initial optimal continuous distension
pressure (CDP) for the best PaO2/FIO2 during HFOV was 2.0±0.6
kPa in ARDSp and 2.8±0.6 kPa in ARDSexp (p<0.01). HFOV recruits
and thus it is more effective in ARDSexp. ARDSexp patients
require higher CDP levels than ARDSp patients. The testing
period for positive effect of HFOV is recommended not to be
longer than 24 hours.
Key words
High-frequency ventilation • High-frequency oscillation • ARDS •
Hypoxemic index • Mechanical ventilation
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