MINIREVIEW
Salsolinol, a Derivate of
Dopamine, is a Possible Modulator of Catecholaminergic
Transmission: a Review of Recent Developments
B. MRAVEC
Institute of Experimental Endocrinology, Slovak Academy of
Sciences and Institute of Pathophysiology, Faculty of Medicine,
Comenius University, Bratislava, Slovak Republic
Received May 31, 2005
Accepted August 17, 2005
On-line available October 17, 2005
Summary
Catecholamine (dopamine, norepinephrine and epinephrine)
synthesizing neurons are widely distributed in the brain,
sympathetic ganglia and throughout peripheral organs. Results of
several recent experiments clearly suggest that many of these
neurons can also contain
1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
(salsolinol), a derivate of dopamine. However, direct proof of
salsolinol synthesis in those neurons is still missing. The data
obtained with administration of exogenous salsolinol strongly
indicate that it may play an important role in catecholaminergic
regulatory processes, such as the regulation of prolactin
release and/or neuronal transmission in sympathetic ganglia.
Several recent data have also indicated a relationship between
salsolinol or its metabolites and the etiology of Parkinson's
disease or neuropathology of chronic alcoholism. These seemingly
different roles of salsolinol will be discussed separately, but
some common features will also be highlighted. Based on all of
the discussed data the existence of a “salsolinolergic” system
using salsolinol as a neuromodulator, which may be present in
catecholamine synthesizing neurons, is postulated.
Key words
Salsolinol • Dopamine • Prolactoliberin • Parkinson’s disease •
1MeDIQ
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