Akce

“Single-cell to tissue-scale memory of infection and inflammation” The role of epithelial and stromal cells in driving inflammation, together with immune cells, is being increasingly appreciated. However, we currently lack tissue-scale frameworks to define and test how inflammation collectively impacts epithelial, stromal, and immune cells. This poses a fundamental challenge for understanding the cellular mechanisms that drive…
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Maternal diet quality and health status of newborns Lecturer: Mgr. Jitka Pavlíková, Ph.D. / Department of Toxicology a Molecular Epidemiology Annotation: Persistent organic pollutants are compounds of mostly anthropogenic origin that persist in the environment for a long time, become part of food chains, and some of them accumulate in living organisms. These substances are being monitored for…
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RNDr. Katarína Smolková, Ph.D., Laboratory of Mitochondrial Physiology, IPHYS  

“The impact of genetic cheating on mammalian reproduction and speciation”  Selfish DNA violate Mendel’s Law of Segregation by biased segregation to the egg cell. This genetic cheating, meiotic drive, is a widespread phenomenon across eukaryotes with associated fitness costs such as fertility issues. I will discuss our recent work on the cell biological mechanism of…
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Prof. Sven Enerbäck, Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Sweden.

“Chromatin ADP-ribosylation in neurodegenerative disease” ADP-ribosylation is a common protein post-translational modification that regulates numerous cellular processes, including transcription, cell proliferation and differentiation, immune and stress responses, aging, and cell death. One of its most extensively studied roles is in DNA damage response and subsequent DNA repair. Moreover, deregulation of ADP-ribose metabolism is linked to…
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Prof. John D. Imig, University of Arkansas for Medical Sciences, USA

“Molecular mechanisms of proteoglycan-mediated semaphorin signaling in axon guidance” The precise assembly of a functional nervous system relies on axon guidance cues. Beyond engaging their cognate receptors and initiating signaling cascades that modulate cytoskeletal dynamics, guidance cues also bind components of the extracellular matrix, notably proteoglycans, yet the role and mechanisms of these interactions remain…
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RNDr. Petr Ježek, DrSc., Laboratory of Mitochondrial Physiology, IPHYS

The dendrite’s sweet spot: Atypical glycosylation of the neuronal surface and impact on synaptic receptor trafficking, structure and function Lecturer: Cyril Hanus, PhD. / The Institute of Psychiatry and Neuroscience of Paris The seminar will take place on 30. 04. 2024 from 10:00 p.m. in the Turquoise Auditorium of the IEM CAS. Annotation: Like 75% of membrane proteins, neurotransmitter receptors and synaptic adhesion molecules…
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μLectures is a monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session, lasting 30 minutes, focuses on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments, giving them a better overview of the options available and enabling…
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Monitoring of telomeres through colorectal adenomas to advanced stages of colorectal cancer Lecturer: Mgr. Kateřina Balounová / Department of the Molecular Biology of Cancer Annotation: Telomeres, repetitive sequences located at the ends of chromosomes, naturally shorten with ageing. Disruption in telomere biology is closely associated with the onset and progression of cancers, including colorectal carcinoma (CRC). Given…
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