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DTSTART;TZID=Europe/Prague:20240605T150000
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DTSTAMP:20260415T102428
CREATED:20240528T080600Z
LAST-MODIFIED:20240528T080600Z
UID:922-1717599600-1717603200@www.biomed.cas.cz
SUMMARY:Seminář Subhadip Chakraborty\, M.Sc.
DESCRIPTION:“Understanding the mechanochemical transitions that underlie early embryo development” \nDuring embryogenesis a single fertilized oocyte develops into an adult organism via tightly controlled patterns of cell division\, cell polarization and cell movements. These mechanical processes depend on the actomyosin cortex\, a thin 2D layer that resides underneath the plasma membrane. Importantly\, for normal development the actomyosin cortex in rapidly dividing embryonic cells needs to transition between contractile and non-contractile phases. Surprisingly little is known about how these mechanical transitions are regulated in a developing embryo. To understand mechanical transitions during embryogenesis\, I use C. elegans early embryos as a model\, and perform quantitative live imaging of the actomyosin cortex as it transitions between contractile and non-contractile phases. In the IMG seminar I will present my recent results in which we demonstrate how two major signaling cascades\, Cdc42 and RhoA\, affect distinct mechanical phases and the transitions between them.
URL:https://www.biomed.cas.cz/event/seminar-subhadip-chakraborty-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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