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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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DTSTART:20240331T010000
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DTSTART;TZID=Europe/Prague:20240626T160000
DTEND;TZID=Europe/Prague:20240626T170000
DTSTAMP:20260415T041730
CREATED:20240612T073038Z
LAST-MODIFIED:20240612T081932Z
UID:932-1719417600-1719421200@www.biomed.cas.cz
SUMMARY:Seminář Prof. Dirk Schübeler
DESCRIPTION:“Finding your place: Transcription factors as sensors and modifiers of chromatin” \nTranscription factors only bind a minority of their motifs in large mammalian genomes. One likely explanation is that many motifs are not accessible for binding due to the action of chromatin and DNA methylation. We are using mammalian stem cell models and their differentiation combined with genomics to understand this important interplay between gene regulation\, chromatin structure and DNA methylation. We study the dynamics of the epigenome and test regulatory models in cellular models by genetic perturbation and genome editing approaches. \nI will discuss our recent efforts in understanding how the sensitivity to DNA methylation and nucleosomes can limit transcription factor binding in the context of the cell and how TFs rely on specific chromatin remodelers for access to their binding sites.
URL:https://www.biomed.cas.cz/event/seminar-prof-dirk-schubeler/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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