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DTSTART;TZID=Europe/Prague:20241113T150000
DTEND;TZID=Europe/Prague:20241113T160000
DTSTAMP:20260418T053729
CREATED:20241104T072334Z
LAST-MODIFIED:20241104T072334Z
UID:2247-1731510000-1731513600@www.biomed.cas.cz
SUMMARY:Seminář Aleš Neuwirth\, Ph.D.
DESCRIPTION:“Unravelling autoimmunity in Addison’s disease using a new mouse model” \nAutoimmune Addison’s disease is a disorder targeting steroid-producing cells in the adrenal glands. Due to the lack of suitable animal models\, the immune mechanisms underlying adrenal destruction remain largely unknown. To address this\, we developed the first defined mouse model of experimental autoimmune adrenalitis by immunizing C57BL/6 mice with immunogenic peptides derived from CYP11A1\, a rate-limiting enzyme in steroidogenesis. This model allows us to study the pathogenesis of Addison’s disease and provides a unique opportunity to investigate the fate decisions of self-reactive CD4+ T cells and their clonal lineages in a well-defined autoimmune setting.
URL:https://www.biomed.cas.cz/event/seminar-ales-neuwirth-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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