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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Prague:20250122T150000
DTEND;TZID=Europe/Prague:20250122T160000
DTSTAMP:20260419T194406
CREATED:20250113T124228Z
LAST-MODIFIED:20250113T124228Z
UID:2282-1737558000-1737561600@www.biomed.cas.cz
SUMMARY:Seminář Michal Mrkáček\, M.Sc.
DESCRIPTION:“Tipping the Lipid Scales: Negative Feedback Regulation via ORMDLs Protein Degradation Ensures Sphingolipid Homeostasis” \nSphingolipids are essential lipid molecules that contribute to cellular structure and signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and catalyzed by the multimeric serine palmitoyltransferase (SPT) complex. The ER-resident ORMDL proteins are well-established regulators of sphingolipid synthesis\, directly inhibiting the SPT complex to control the pathway at its origin. Here\, we identify a negative feedback loop that fine-tunes this regulatory mechanism. Using pharmacological inhibitors such as myriocin and fumonisin B1\, which target different steps of the sphingolipid pathway\, we demonstrate that reduced sphingolipid levels promote enhanced degradation of ORMDL proteins. This degradation alleviates SPT inhibition\, thereby accelerating de novo sphingolipid biosynthesis and restoring metabolic balance.
URL:https://www.biomed.cas.cz/event/seminar-michal-mrkacek-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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