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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Prague:20250129T150000
DTEND;TZID=Europe/Prague:20250129T160000
DTSTAMP:20260419T170942
CREATED:20250114T125756Z
LAST-MODIFIED:20250114T125756Z
UID:2284-1738162800-1738166400@www.biomed.cas.cz
SUMMARY:Seminář Mgr. et Mgr. Evžen Bouřa\, Ph.D.
DESCRIPTION:“RNA cap methylation in poxviruses and coronavirus – differences and similarities” \nRNA methyltransferases (MTases) are responsible for synthesizing the 5′ RNA cap\, which plays a crucial role in RNA stability and efficient translation. Over the past two years\, both our research team and others have developed numerous inhibitors targeting coronaviral MTases. Through our efforts\, we have successfully determined the crystal structures of these inhibitors bound to the coronaviral nsp14 and nsp16/nsp10 MTases. Additionally\, we recently elucidated the crystal structure of the monkeypox virus MTase VP39\, in complex with the broad-spectrum MTase inhibitor sinefungin and several other inhibitors. These structural studies have unveiled notable distinctions between coronaviral and poxviral MTases\, while also highlighting the potential for targeting these enzymes with the same or closely related compounds.
URL:https://www.biomed.cas.cz/event/seminar-mgr-et-mgr-evzen-boura-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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