BEGIN:VCALENDAR
VERSION:2.0
PRODID:-// - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250416T150000
DTEND;TZID=Europe/Prague:20250416T160000
DTSTAMP:20260421T162152
CREATED:20250407T122503Z
LAST-MODIFIED:20250407T122503Z
UID:2351-1744815600-1744819200@www.biomed.cas.cz
SUMMARY:Seminář Goncalo Oliveira\, Ph.D.
DESCRIPTION:“Deciphering PNKP Functions in Neurological Disorders” \nHereditary mutations in polynucleotide kinase-phosphatase (PNKP)\, a key enzyme in DNA strand break repair\, result in a broad spectrum of neurological disorders\, ranging from mild neurodegeneration to severe neurodevelopmental defects. PNKP has dual phosphatase and kinase activities essential for DNA break repair\, but their specific contributions to preventing neuropathology remains unclear. In this seminar\, we will present findings from mouse genetic models that highlight the crucial role of the PNKP phosphatase domain in neurodevelopment. Additionally\, we will introduce a novel cell-based system to investigate the immediate effects of acute PNKP depletion and explore how this model helps identify key sources of DNA damage and the molecular mechanisms underlying PNKP-related disease pathology.
URL:https://www.biomed.cas.cz/event/seminar-goncalo-oliveira-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR