BEGIN:VCALENDAR
VERSION:2.0
PRODID:-// - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250428T100000
DTEND;TZID=Europe/Prague:20250428T110000
DTSTAMP:20260421T193635
CREATED:20250424T060007Z
LAST-MODIFIED:20250424T060007Z
UID:2370-1745834400-1745838000@www.biomed.cas.cz
SUMMARY:Seminar: "The unfolded protein sensor IRE1 as a regulator of homeostatic dendritic cell maturation"
DESCRIPTION:Dear friends and colleagues\, \nit is my pleasure to invite you to a special seminar given by \n\n \n                      Prof. Sophie Janssens\, PhD. \nVIB-UGent Center for Inflammation Research\, Belgium \nTitle: The unfolded protein sensor IRE1 as a regulator of homeostatic dendritic cell maturation  \n  \nMonday\, April 28\, 2025 at 10 am\, in Hasek’s lecture hall\, Institute of Molecular Genetics (Videnska 1083) \nThen\, after the seminar you are invited to join us for an informal post-seminar hangout with the speaker\, 🍕 A PIZZA TALK 🍕🎤 Open Q&A on science\, careers\, life in academia\, women in science & more.👩‍🔬 For students & early-career scientists.🍕 Yes\, there will be pizza. \nProf. Sofie Janssens’s research team focuses on the role of the unfolded protein response (UPR) in several immune cell types. Their recent work has shown that the UPR is an important component in the functioning of the immune system. In CD8α conventional dendritic cells (DCs) the UPR sensor IRE-1α and its downstream transcription factor XBP-1s is constitutively active and deficiency of XBP-1s leads to defects in cross-presentation of dead cell-derived antigens. \nExamples of recent publications: \nStriking a balance: new perspectives on homeostatic dendritic cell maturation.\nBosteels Victor\, Janssens Sophie \nNATURE REVIEWS. IMMUNOLOGY\, 125-140\, 25\, 2025 \nDOI: 10.1038/s41577-024-01079-5 \nPaneth cell TNF signaling induces gut bacterial translocation and sepsis.\nWallaeys Charlotte\, Garcia Gonzalez Natalia\, Timmermans Steven\, Vandewalle Jolien\, Vanderhaeghen Tineke\, De Beul Somara\, Dufoor Hester\, Eggermont Melanie\, Moens Elise\, Bosteels Victor Show more \nCELL HOST & MICROBE\, 1-19\, 32\, 2024 \nDOI: 10.1016/j.chom.2024.08.007 \nActivation of goblet-cell stress sensor IRE1ß is controlled by the mucin chaperone AGR2.\nCloots Eva\, Guilbert Phaedra\, Provost Mathias\, Neidhardt Lisa\, Van De Velde Evelien\, Fayazpour Farzaneh\, De Sutter Delphine\, Savvides Savvas\, Eyckerman Sven\, Janssens Sophie \nTHE EMBO JOURNAL\, 695-718\, 43\, 2024 \nDOI: 10.1038/s44318-023-00015-y \nThe IRE1ß-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.\nNeidhardt Lisa\, Cloots Eva\, Friemel Natalie\, Weiss Caroline A\, Harding Heather\, Mclaughlin Stephen\, Janssens Sophie\, Ron David \nTHE EMBO JOURNAL\, 719-753\, 43\, 2024 \nDOI: 10.1038/s44318-023-00014-z \nCanonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.\nVetters Jessica\, Van Helden Mary\, De Nolf Clint\, Rennen Sofie\, Cloots Eva\, Van De Velde Evelien\, Fayazpour Farzaneh\, Van Moorleghem Justine\, Vanheerswynghels Manon\, Vergote Karl Show more \nISCIENCE\, 108570\, 26\, 2023 \nDOI: 10.1016/j.isci.2023.108570 \nLXR signaling controls homeostatic dendritic cell maturation.\nBosteels Victor\, Marechal Sandra\, De Nolf Clint\, Rennen Sofie\, Maelfait Jonathan\, Tavernier Simon\, Vetters Jessica\, Van De Velde Evelien\, Fayazpour Farzaneh\, Deswarte Kim Show more \nSCIENCE IMMUNOLOGY\, eadd3955\, 8\, 2023 \nDOI: 10.1126/sciimmunol.add3955 \n— Dominik Filipp\, PhD Laboratory of Immunobiology Institute of Molecular Genetics AS CR Videnska 1083 CZ-142 20 Prague 4 Czech Republic
URL:https://www.biomed.cas.cz/event/seminar-the-unfolded-protein-sensor-ire1-as-a-regulator-of-homeostatic-dendritic-cell-maturation/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR