BEGIN:VCALENDAR
VERSION:2.0
PRODID:-// - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250528T150000
DTEND;TZID=Europe/Prague:20250528T160000
DTSTAMP:20260420T054832
CREATED:20250519T133610Z
LAST-MODIFIED:20250519T133610Z
UID:2384-1748444400-1748448000@www.biomed.cas.cz
SUMMARY:Seminář Alexandra Urbančoková\, M.Sc.
DESCRIPTION:“PML nucleolar association: What is it and what does it do?” \nPromyelocytic leukemia protein (PML) is a multivalent stress response protein that\, upon specific genotoxic stress\, can organize into a unique structure that encloses nucleolar material\, termed the PML-nucleolar association (PNA). PNAs were described in both senescent cells and cells harboring DNA damage. We investigated the origin\, dynamics\, and signaling pathways leading to PNA formation. Our recent findings suggest that PNAs are involved in ribosomal DNA (rDNA) damage response by sequestration of persistent rDNA lesions and promote cellular senescence. Further analysis of PNA-associated proteins reinforces their involvement in the rDNA damage response. Together\, these insights contribute to a more comprehensive understanding of the functional relevance of PNAs in rDNA maintenance and cellular genotoxic stress response.
URL:https://www.biomed.cas.cz/event/seminar-alexandra-urbancokova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR